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http://www.americanpharmaceuticalreview.com/Featured-Articles/148744-Key-Targeting-Approaches-for-Pharmaceutical-Drug-Delivery/
Oct 25, 2013 · Drug targeting is defined as the ability of a drug molecule to accumulate in the target organ or tissue selectively such that the concentration of the drug at the disease site is high, while its concentration in nontarget organs and tissues is low, preferably, below certain minimal level so as to prevent any toxic effect. Thus, drug targeting can overcome the non-specific toxic effect of ...
https://www.intechopen.com/books/advanced-technology-for-delivering-therapeutics/introductory-chapter-drug-delivery-concepts
Drug delivery systems (DDSs) are pharmaceutical formulations or devices that help in achieving targeted delivery and/or controlled release (CR) of therapeutic agents in our body [].Following administration, the DDSs liberate the active ingredients, and subsequently, the bioactive molecules are transported across various biological barriers to reach the site of action.Author: Sabyasachi Maiti, Kalyan Kumar Sen
https://mcgovern.mit.edu/2019/08/19/a-new-way-to-deliver-drugs-with-pinpoint-targeting/
And the system is broadly applicable for drug delivery: “we can encapsulate any water-soluble drug,” and with some adaptations, other drugs as well, she says. One key to developing this system was perfecting and calibrating a way of making liposomes of a highly uniform size and composition.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
Although solid NPs may be used for drug targeting, when reaching the intended diseased site in the body the drug carried needs to be released. So, for drug delivery biodegradable nanoparticle formulations are needed as it is the intention to transport and release the drug in order to be effective.Author: Wim H De Jong, Paul Ja Borm
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Current research on drug delivery systems can be described in four broad categories: routes of delivery, delivery vehicles, cargo, and targeting strategies. Routes of Delivery. Medications can be taken in a variety of ways—by swallowing, by inhalation, by absorption through the skin, or by intravenous injection.
https://www.sciencedirect.com/science/article/pii/S0928098700001664
To illustrate opportunities and challenges of drug targeting, further, we will consider several examples of targeted drug delivery within the cardiovascular system, since this system demonstrates a broad variety of targets that can be reached by various targeting methods. 3. Targeting of pharmaceuticals within the cardiovascular system
https://www.researchgate.net/publication/297283078_Targeted_Drug_Delivery_A_Review
1981, described the use of novel drug delivery for drug targeting as „old drug in new clothes‟ 3. Conventional dosage forms such as injections, oral formulations comprising of solut ions and
https://www.slideshare.net/anvitaj1/drug-targeting-42888705
Dec 20, 2014 · Drug targeting 1. Presented by: Anvita M. Pharm (IP) 2. What is drug targeting The therapeutic response of a drug depends upon the interaction of drug molecules with cell on cell membrane related biological events at receptor sites in concentration dependent manner. Selective and effective localization of the pharmacologically-active moiety at prei
https://www.tandfonline.com/doi/abs/10.1080/1061186X.2017.1401076
Nov 15, 2017 · Developing a new drug molecule is not only time-consuming and expensive, but also mostly a failing process. However, improving bioavailability, targetability, efficacy or safety of old drugs could be more effective way to use them in clinic.Author: Kıvılcım Öztürk-Atar, Hakan Eroğlu, Sema Çalış
https://www.sciencedirect.com/science/article/pii/S1369702105710336
Download : Download high-res image (560KB) Download : Download full-size image Fig. 1.Schematic of two different targeted nanoparticle drug delivery systems. (A) Liposomal-based systems are vesicular with targeting or PEG groups either preconjugated with a lipid then formed into a vesicle or postinserted into the liposome.Author: Tarek M. Fahmy, Peter M. Fong, Amit Goyal, W. Mark Saltzman
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