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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038673/
This work introduced a minimally invasive strategy for drug delivery to the back of the eye. It showed that a hollow microneedle can inject liquid solution and suspensions of particles into the suprachoroidal space of rabbit, pig, and human eyes ex vivo. Suprachoroidal delivery represents an improvement over current periocular and intravitreal ...Author: Samirkumar R. Patel, Angela S. P. Lin, Henry F. Edelhauser, Mark R. Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
http://www.eyecenter.emory.edu/press_releases/pr_faculty_31.htm
(ATLANTA) A new textbook, Drug Product Development for the Back of the Eye (aapspress/Springer), edited by Emory Eye Center researcher Henry F. Edelhauser, PhD and Uday B. Kompella, PhD, of the University of Colorado, explores approaches for a delivery system to get drugs to the back of the eye. In the past, drug delivery was typically systemic ...
https://medicalxpress.com/news/2019-10-advance-drug-eluting-contact-lenses-delivery.html
Oct 02, 2019 · Drug-eluting contact lenses, which gradually release drugs into the eye, offer a promising alternative to daily eye drops, which can be unpleasant and hard for patients to properly administer. In ...
https://www.researchgate.net/publication/259983962_Drug_Delivery_to_the_Back_of_the_Eye_Following_Topical_Administration_An_Update_on_Research_and_Patenting_Activity
Drug delivery to the back of the eye following topical administration remains an unmet need for the scientific community. Treatment of posterior segment diseases requires localized and long-term ...
https://link.springer.com/chapter/10.1007%2F978-1-4419-9920-7_5
Jun 20, 2011 · Abstract. A topical eye drop represents the least invasive method for targeting drugs to the back of the eye. Systemic exposure and potential toxicity are minimized relative to oral drugs, and an eye drop offers a more patient-friendly experience compared to intravitreal or periocular injections.Author: Thomas Gadek, Dennis Lee
http://drugdelivery.chbe.gatech.edu/Papers/2007/Jiang%20IOVS%202007.pdf
Coated Microneedles for Drug Delivery to the Eye Jason Jiang,1,2 Harvinder S. Gill,3 Deepta Ghate,1 Bernard E. McCarey,1 Samir R. Patel,2 Henry F. Edelhauser,*,1 and Mark R. Prausnitz*,2,3 PURPOSE. To test the hypothesis that coated microneedles can deliver drugs into …
https://medicalxpress.com/news/2012-01-startup-million-drug-delivery-eye.html
Jan 05, 2012 · Startup receives $4 million to develop drug delivery targeted to the back of the eye by Emory University This is researcher Samir Patel with an example of the ocular microneedle device.
https://newatlas.com/microneedles-georgia-tech-back-eyes/23438/
Microneedles improve drug delivery to the back of the eye July 26, 2012 ... The microneedles are a more efficient and less traumatic tool for delivering therapeutic drugs to the back of the eye.
http://drugdelivery.chbe.gatech.edu/Papers/2011/Patel%20Pharm%20Res%202011.pdf
effective drug delivery system targeting the back of the eye would provide a significant improvement in the management of these vision-threatening diseases. An effective drug delivery system for the back of the eye should embody four general characteristics. First, it should be minimally invasive and safe, so as to avoid complications
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