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https://en.wikipedia.org/wiki/Ophthalmic_drug_administration
Ophthalmic drug administration is the administration of a drug to the eyes, most typically as an eye drop formulation. Topical formulations are used to combat a multitude of diseased states of the eye. These states may include bacterial infections, eye injury, glaucoma, and dry eye. However, there are many challenges associated with topical delivery of drugs to the cornea of the eye.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
Concentration of drug available in the precorneal area acts as a driving force for its passive diffusion across cornea. However, for efficient ocular drug delivery with eye drops, high corneal permeation with longer drug cornea contact time is required. Several efforts have been made toward improving precorneal residence time and corneal ...Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
http://samples.jbpub.com/9781284025682/9781449674250_CH10.pdf
Ocular Drug Delivery AswAni Dutt VADlApuDi, Kishore CholKAr, supriyA reDDy DAsAri, AnD Ashim K. mitrA CHAPTER OBJECTIVES Upon completing this chapter, the reader should be able to Describe the anatomy and physiology of the eye. Understand the importance of various routes of drug administration to the eye. Describe various barriers to ocular drug delivery and constraints with
http://drugdelivery.chbe.gatech.edu/Papers/1998/Prausnitz%20J%20Pharm%20Sci%201998.pdf
REVIEW ARTICLE Permeability of Cornea, Sclera, and Conjunctiva: A Literature Analysis for Drug Delivery to the Eye MARK R. PRAUSNITZ* AND JEREMY S. NOONAN Contribution from Schools of Chemical Engineering and Biomedical Engineering, Georgia Institute of …
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https://www.reviewofophthalmology.com/article/into-the-eye-two-new-ways-to-deliver-drugs
Jan 22, 2010 · Into the Eye: Two New Ways to Deliver Drugs ... The EyeGate II iontophoresis drug delivery device uses electrochemical repulsion to drive charged drug molecules out of a solvent solution and into the eye. The instrument features a small ocular applicator that's hollow in the center, with a doughnut-shaped foam reservoir that holds the solution ...
https://www.slideshare.net/pharmD_maha/ocular-drug-delivery-system-48322893
May 19, 2015 · Ocular Drug Delivery System. 1. Ocular Drug Delivery System Dr.Samar Alshawaa, Dr.Etdal Fouda. Presented by: Maha Al-Khalifah, Majd Al-Sarhani and Reem Al-Saif. Basic Principles of Pharmaceutical Sciences. (PHS 201 M) 2. Table of Contents Introduction Structure of the eye. Eye layers. Lacrimal apparatus. Composition of the the eye.
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