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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846103/
Drug Release Kinetics and Transport Mechanisms of Non-degradable and Degradable Polymeric Delivery Systems. ... An increase of drug release was observed with a higher drug diffusion coefficient. Also, case II behavior was observed as α (α = A/B) ... where C w is the time-dependent …Author: Yao Fu, Weiyuan John Kao
https://www.sciencedirect.com/science/article/pii/S0168365911009588
1. Introduction. The mechanistic realistic mathematical description of mass transport in controlled drug delivery systems can be highly beneficial , , , , : firstly, it can allow getting deeper insight into the mechanisms, which control drug release from a particular type of dosage forms , , , , , , , , .Thus, the safety of the respective treatment can be improved.Author: Juergen Siepmann, Juergen Siepmann, Florence Siepmann, Florence Siepmann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719420/
Poly-lactic-co-glycolic acid (PLGA) has been the most successful polymeric biomaterial for use in controlled drug delivery systems. There are several different chemical and physical properties of PLGA that impact the release behavior of drugs from PLGA delivery devices.Author: Daniel J. Hines, David L. Kaplan
https://saliterman.umn.edu/sites/saliterman.dl.umn.edu/files/general/drug_delivery.pdf
Finite element analysis of time-dependent species transport. Images show cut view of species concentration every 5 s up to 25 s after the ejection process (a) electroosmosis only (b) electrophoresis and electroosmosis. Aram J. Chung, Donn Kim, and David Erickson. 2008. Electrokinetic microfluidic devices for rapid, low power drug delivery in
https://www.mdpi.com/2079-4991/9/10/1451/htm
Alginate as a good drug delivery vehicle has excellent biocompatibility and biodegradability. In the ionic gelation process between alginate and Ca2+, the violent reaction is the absence of a well-controlled strategy in the synthesizing calcium alginate (CaA) microgels. In this study, a concentration-controlled microfluidic chip with central buffer flow was designed and 3D-printed to well ...Author: Shixuan Cai, Hongyan Shi, Guoqian Li, Qilu Xue, Lei Zhao, Fu Wang, Bo Hu
https://www.frontiersin.org/articles/10.3389/fbioe.2019.00037/full
By using biodegradable polymers a drug delivery over a time span of weeks or even months is made possible. ... with the unknown diffusion coefficient of the drug in the ... Quantitative results for time-dependent diffusion coefficients in a degrading polymer matrix were presented based on this closed-form 1D diffusion model for a thin film ...Author: Innocent J. Macha, Innocent J. Macha, Besim Ben-Nissan, Elena N. Vilchevskaya, Anna S. Morozova, Bil...
https://www.sciencedirect.com/science/article/pii/0168365985900513
Only few attempts have been made to model such swelling-controlled release systems. Good [8] employed a time-dependent drug diffusion coefficient which was set to be proportional to the fractional solvent absorption. The results were used to fit experimental diffusion data for …Author: Ping I. Lee
https://www.frontiersin.org/articles/10.3389/fncel.2019.00161/full
The diffusion coefficient k d is known but the clearing coefficient k c is unknown. The ratio of the diffusion and clearing coefficients can, however, be found via fitting the experimental data. The physical meaning of k d /k c can be described as the ratio between the amount of substance that diffuses through a unit surface normal to the direction of diffusion for a unit concentration ...Author: Ildar I. Sadreev, George W. S. Burwood, Samuel M. Flaherty, Jongrae Kim, Ian J. Russell, Timur I. Ab...
https://en.wikipedia.org/wiki/Fick%27s_laws_of_diffusion
Fick's laws of diffusion describe diffusion and were derived by Adolf Fick in 1855. They can be used to solve for the diffusion coefficient, D.Fick's first law can be used to derive his second law which in turn is identical to the diffusion equation.. A diffusion process that obeys Fick's laws is called normal diffusion (or Fickian diffusion); otherwise, it's called Anomalous diffusion (or non ...
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