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https://www.researchgate.net/publication/240029506_Drug_Delivery_through_Phagocytosis_of_Red_Blood_Cells
Alternatively, drug-loaded red cells can be modified to increase their phagocytosis by inducing band 3 clustering and opsonization by autologous IgGs and complement (up to C3b).
https://www.researchgate.net/profile/Laura_Chiarantini/publication/240029506_Drug_Delivery_through_Phagocytosis_of_Red_Blood_Cells/links/00b4953abe3b2e6740000000/Drug-Delivery-through-Phagocytosis-of-Red-Blood-Cells.pdf
the same donor the circulating red cells behave as a slow drug delivery system. Alternatively, drug-loaded red cells can be modified to increase their phagocytosis by induc-
https://www.academia.edu/12575060/Drug_Delivery_through_Phagocytosis_of_Red_Blood_Cells
Drug Delivery through Phagocytosis of Red Blood Cells
https://www.academia.edu/12528616/Drug_Delivery_through_Phagocytosis_of_Red_Blood_Cells
Drug Delivery through Phagocytosis of Red Blood Cells
https://www.nature.com/articles/s41467-018-04791-8
Jun 15, 2018 · RNA delivery for disease treatment often has low uptake efficiencies and cytotoxicity. Here the authors produce extracellular vesicles from red blood cells for in vivo cargo delivery.Author: Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok, Luyen Tien Vu, Victor Ma, Boya Peng, Yuen San Ch...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844929/
Introduction: red blood cells as carriers for drug delivery The optimization of vascular delivery of drugs is an important biomedical problem. This problem is especially acute in case of delivery of potent and specific, yet labile and complex biotherapeutic agents including enzymes, which in most cases require precise localization in the target site.
https://www.onlinelibrary.wiley.com/doi/pdf/10.1002/smtd.201700270
Nov 14, 2017 · Red blood cells (RBCs), or erythrocytes, have been promising endogenous candidates for drug delivery for more than four decades. Armed with a better understanding of the diverse mechanisms and paths for drug delivery, researchers have achieved great progress in manufacturing RBC‐based carriers, from both the scientific and clinical viewpoints.Author: Junjie Yan, Jicheng Yu, Chao Wang, Zhen Gu
https://www.nature.com/articles/s41467-018-05079-7
Jul 11, 2018 · Unwanted uptake in the liver and limited accumulation in target organs is a major obstacle to targeted drug delivery. Here, the authors report on the hitchhiking of nanocarriers on red blood cells ...Author: Jacob S. Brenner, Daniel C. Pan, Jacob W. Myerson, Oscar A. Marcos-Contreras, Carlos H. Villa, Priya...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396668/
Red blood cells (RBC) have a life span of 120 days in humans and about 45 days in mice. 1 Removal of senescent RBC (sRBC) from the circulation occurs through phagocytosis (erythrophagocytosis, EPC), which takes place mainly in macrophages of the spleen, but also in the liver and the bone marrow. 2 Macrophages recognize sRBC by a range of senescence markers. 3 Following recognition and …Author: Yehonathan Gottlieb, Orit Topaz, Lyora A. Cohen, Liat David Yakov, Tom Haber, Abigail Morgenstern, A...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906564/
Jan 30, 2014 · Macrophages tightly control the production and clearance of red blood cells (RBC). During steady state hematopoiesis, approximately 10 10 RBC are produced per hour within erythroblastic islands in humans.Author: Djuna Zoe de Back, Elena Bagrianova Kostova, Marian van Kraaij, Timo Kars van den Berg, Robin Van Br...
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