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https://www.ncbi.nlm.nih.gov/pubmed/25594406
Systemic drug delivery systems for bone tissue regeneration- a mini review. ... As a rapid-developing biotechnology, systemic bonetargeting delivery system is promising but still in its infancy where challenges are ahead of us, including the stability and the toxicity issues, especially to fulfill the regulatory requirement to realize bench-to ...Author: Wang Xinluan, Lai Yuxiao, Ng HueiLeng Helena, Yang Zhijun, Qin Ling
https://link.springer.com/article/10.2165/00003088-200342150-00002
Sep 13, 2012 · Despite several decades of progress, bone-specific delivery is still limited by the unique anatomical features of bone, which mainly consists of inorganic hydroxyapatite. A practical approach to this problem is to produce targeted drugs that have a high affinity for hydroxyapatite. Bisphosphonates are a class of synthetic compounds structurally related to pyrophosphate. Bisphosphonates rapidly ...Author: Hideki Hirabayashi, Jiro Fujisaki
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Other NIBIB-funded researchers are developing a system of drug delivery using a type of bacteria that has a two-part navigation system—magnetic and oxygen sensing. They have tested the delivery system in mice, achieving a remarkable success delivering drugs to tumors. The bacteria seek out oxygen-poor zones, which are a feature of tumors.
https://www.sciencedirect.com/topics/nursing-and-health-professions/drug-delivery-system
Drug Delivery System. A drug delivery system (DDS) is defined as a formulation or a device that enables the introduction of a therapeutic substance into the body and improves its efficacy and safety by controlling the rate, time, and place of release of drugs in the body.
https://news.wsu.edu/2019/06/20/timed-release-turmeric-stops-cancer-cell-growth/
Jun 20, 2019 · A WSU research team has developed a drug delivery system using curcumin, the main ingredient in the spice turmeric, that successfully inhibits bone cancer cells while promoting growth of healthy bone cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571930/
Sep 08, 2015 · Bone-targeting NPs, which were based on the conjugation of TC to PLGA copolymers, have the ability to target bone. These NPs may be developed as a delivery system for hydrophobic drugs, and they are expected to improve the curative effects of drugs, reduce the administered drug doses, and reduce side effects in other organs.Author: Hua Wang, Jun Liu, Shan Tao, Guihong Chai, Jianwei Wang, Fu-Qiang Hu, Hong Yuan
https://medicalxpress.com/news/2018-10-delivery-drugs-cancer-cells-bone.html
Oct 30, 2018 · Researchers design delivery system to guide drugs directly to cancer cells 'hiding' in bone marrow ... which they termed "cell combination drug delivery," is the first to link two different cells ...
https://asbmr.onlinelibrary.wiley.com/doi/pdf/10.1359/jbmr.2000.15.5.936
Selective Drug Delivery System to Bone: Small Peptide (Asp)6 Conjugation* SHOHEI KASUGAI,1 RYUICHI FUJISAWA,2 YOSHIHIRO WAKI,1 KEN-ICHI MIYAMOTO,3 and KEIICHI OHYA4 ABSTRACT Targeting a drug on hydroxyapatite (HA) could be a promising way for selective drug delivery to bone,Author: Shohei Kasugai, Ryuichi Fujisawa, Yoshihiro Waki, Ken‐Ichi Miyamoto, Keiichi Ohya
https://pubs.acs.org/doi/10.1021/bc034090j
Pharmacokinetic and Biodistribution Studies of a Bone-Targeting Drug Delivery System Based on N-(2-Hydroxypropyl)methacrylamide Copolymers. Molecular Pharmaceutics 2006 , 3 (6) , 717-725.Author: Dong Wang, Scott C Miller, Monika Sima, Pavla Kopečková, Jindrich Kopecek
https://www.sciencedirect.com/science/article/abs/pii/S875632821830231X
Together, our findings have identified that, (AspSerSer) 6, a bone-targeting drug-delivery system based on semaphorin3A gene therapy, ameliorated bone loss in osteoporotic ovariectomized mice, by suppressing osteoclastic bone resorption and simultaneously increasing osteoblastic bone formation. Gene therapy by local site-specific Sema3A ...Author: K. Yang, R.J. Miron, R.J. Miron, Z. Bian, Y.F. Zhang
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