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https://www.pharmaceutical-journal.com/drug-delivery-progress-and-problems/20003039.fullarticle
Drug delivery: progress and problems. Four half-day sessions at the Conference were devoted to discussion on aspects of drug delivery. The biochemical barriers that can hinder effective drug delivery, and possible ways of overcoming them, were discussed by several Conference speakers.
https://www.omicsonline.org/conferences-list/major-challenges-in-drug-delivery-system
Major Challenges in Drug Delivery Systems are delivery of poorly soluble drugs and bioavailability hurdles for poorly soluble clinical candidates. There are several Novel approaches in the delivery, Overcoming bioavailability hurdles and Rationale formulation design of poorly soluble drugs.
https://www.ncbi.nlm.nih.gov/books/NBK200818/
These findings raise the possibility of treating osteomyelitis with a combination of an antibiotic and a suitable protease, but delivery becomes the problem. “If you can’t get vancomycin out of bone cement, you’re not going to get a protease out either,” explained Smeltzer.Author: Division on Earth
https://www.myamericannurse.com/advocating-for-patients-in-an-era-of-drug-delivery-problems/
Jul 11, 2013 · Another serious drug-delivery issue is shortages of important drugs, most of them injectables. In 2010, 178 drugs were reported to be in short supply and no longer available for patient care. In 2011, when the shortages peaked, 215 drugs were in short supply—most of them liquid injectable drugs commonly used in critical care.
https://essentials.asme.org/bioengineering/engineering-solutions-to-drug-delivery-challenges
While SPRITAM resolved problems related to large load drug delivery, the drug Yutiq addresses another headache for engineers: how to get the medicine to where it is needed. In this case, the drug (fluocinolone acetonide) is released through a tiny implant injected into the eye to treat posterior uveitis, a potentially blinding eye disease.
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Working backwards is sometimes an effective way to solve a problem. In drug delivery research, this means starting with a delivery method. The target may be whole organs (heart, lung, brain), tissue types (muscle, nerve), disease-specific structures (tumor cells), or structures inside of cells.
http://www.pharmtech.com/four-challenges-pulmonary-drug-delivery
Sep 01, 2017 · Pulmonary drug delivery is receiving increased attention as a non-invasive means for local treatment of a wide range of major lung diseases; this route of administration, however, poses additional challenges for medicinal and formulation chemists.
http://www.americanpharmaceuticalreview.com/Featured-Articles/345540-Opportunities-and-Challenges-in-Biologic-Drug-Delivery/
Dec 22, 2017 · These drugs have two other problems. They are difficult to make and they are hard for patients to take. As such, they require a de-risking strategy that employs a new, patient-focused drug delivery system coming to market. How Drug Administration Costs Can Limit Successful Commercialization of Biologic Drugs
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635663/
Apr 22, 2013 · A major disadvantage of microbubbles as drug delivery systems is their relatively large size (1–10 μm), which is a problem for microbubbles needing to penetrate through the epithelial cells of the vasculature to the target tissue.Author: Ying-Zheng Zhao, Li-Na Du, Cui-Tao Lu, Yi-Guang Jin, Shu-Ping Ge
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