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https://www.sciencedirect.com/science/article/pii/S1359644610008421
Drug delivery to the posterior segment of the eye is therefore compounded by the increasing number of new therapeutic entities (e.g. oligonucleotides, aptamers and antibodies) and the need for chronic therapy. Currently, the intravitreal route is widely used to deliver therapeutic entities to the retina.Author: Thilini Rasika Thrimawithana, Simon Young, Craig Robert Bunt, Colin Green, Raid Ghassan Alany
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839363/
Feb 01, 2010 · Treatment of diseases of the posterior segment of the eye, such as age-related macular degeneration, cytomegalovirus retinitis, diabetic retinopathy, posterior uveitis and retinitis pigmentosa, requires novel drug delivery systems that can overcome the many barriers for efficacious delivery of therapeutic drug concentrations.Author: Shalin S Shah, Lori Vidal Denham, Jasmine R Elison, Partha S Bhattacharjee, Christian Clement, Tashf...
https://www.sciencedirect.com/science/article/pii/S0753332218306863
Major proportion of market of ophthalmic products is occupied by topical formulations which includes eye drops (major), eye ointments, contact lens, cul-de-sac inserts, punctual plugs etc. Being the most convenient and efficacious non-invasive route, it is the most preferred especially for drug delivery to anterior segment.Author: Kritika Nayak, Manju Misra
https://www.researchgate.net/publication/47810056_Drug_delivery_to_the_posterior_segment_of_the_eye
Abstract. Drug delivery into the posterior segment of the eye is complicated by the presence of the blood-ocular barrier. Strategies for delivering drugs to the posterior segment include systemic ...
https://www.ncbi.nlm.nih.gov/pubmed/20703044
Drug delivery into the posterior segment of the eye is complicated by the existence of the blood-ocular barrier. Strategies for delivering drugs to the posterior segment include systemic administration, modification of the barrier, and local drug delivery (including transcorneal, transscleral, and ...Author: Baruch D Kuppermann, Anat Loewenstein
https://www.slideshare.net/meenankbheeshva/drug-delivery-to-the-posterior-segment-of-the-eye-for-pharmacologic-therapy-31241280
Feb 15, 2014 · Drug delivery to the posterior segment of the eye for pharmacologic therapy 1. Drug delivery to the posterior segment of the eye for pharmacologic therapy Dr. Meenank. B M.S. Ophthalmology (Post-Graduate ) ASRAM medical college 2.
https://www.ondrugdelivery.com/sustained-drug-delivery-posterior-segments-eye/
When administered topically, drug concentrations in the retina and choroid are many-fold lower than the tear fluid. Drug delivery to the posterior segment of the eye is most efficiently achieved by local, ocular routes of administration, which includes intravitreal, subretinal, suprachoroidal and …
https://www.oraclinical.com/resource/ocular-drug-delivery-targeting-the-posterior-segment/
This is why delivering drugs effectively to the posterior of the eye is a challenge that many companies have aimed to overcome. This installment of the Innovations in Retina column describes recent developments in methods of ophthalmic drug delivery to the posterior segment of …
https://www.aao.org/eyenet/article/drug-delivery-for-the-posterior-segment
A Legacy of Innovation. Today’s innovations are part of a pioneering legacy in research for vitreoretinal diseases. Dr. Grewal points to Vitrasert (Chiron, later Bausch + Lomb), the first sustained-release posterior segment drug delivery system that laid some of the foundation for today’s breakthroughs.
http://retinatoday.com/2015/09/drug-delivery-to-the-posterior-segment
Drug delivery to the posterior segment of the eye is an area of intense investigation and immense potential. Despite the emergence of effective drugs to treat a variety of retinal diseases, surgeons still grapple with how best to administer these sight-saving medications.
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