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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347861/
Sep 01, 2011 · In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications.PLGA is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a FDA approved polymer.Author: Hirenkumar K. Makadia, Steven J. Siegel
https://www.ncbi.nlm.nih.gov/pubmed/15719481
PLGA nanoparticles in drug delivery: the state of the art. Bala I(1), Hariharan S, Kumar MN. Author information: (1)Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India. Nanoparticles represent drug delivery systems suitable for most administration routes.Author: Indu Bala, Sarita Hariharan, Mnv Ravi Kumar
https://www.sigmaaldrich.com/technical-documents/articles/materials-science/plga-drug-delivery.html
Solubility enhancement of hydrophobic drugs via drug-loaded micelles using biodegradable PEG- polyester diblock copolymers The requirement for large quantities of saline to dissolve such materials limits their clinical use, and one solution for this problem that has recently generated interest is the formation of drug-loaded micelles.
https://drug-dev.com/microfluidic-encapsulation-controlling-drug-delivery-with-plga/
An example of this is PLGA nanostructures that combine drug delivery, molecular imaging, and real-time monitoring of therapeutic response, which are paving the way for nanomedicine in the future. The use of PLGA and microfluidics is showing tremendous promise in drug delivery, and it will be exciting to see how this technology continues to grow.
https://www.researchgate.net/publication/270765946_PLGA_A_unique_polymer_for_drug_delivery
PLGA: A unique polymer for drug delivery. ... A wide range of PLGA-based drug delivery systems have been reported for the treatment or diagnosis of various diseases and disorders. The present ...
https://www.sciencedirect.com/science/article/pii/S0378517307008630
The mobility of a drug in PLGA-based delivery systems does not only depend on its own physico-chemical properties and the type of PLGA used, but also to a large extent on the size and shape of the device. In addition, attractive ionic drug-polymer interactions can lead to unexpected low release rates.Author: D. Klose, D. Klose, F. Siepmann, K. Elkharraz, J. Siepmann, J. Siepmann
https://www.sigmaaldrich.com/technical-documents/articles/technology-spotlights/degradex-microspheres-nanoparticles.html
Degradex ® PLGA Particles. Degradex ® PLGA microspheres and nanoparticles are polymeric particles in the size range of nanometers to microns. Both plain and fluorescently dyed particles are available. Plain PLGA microspheres and nanoparticles can be used in drug delivery research and formulation as control agents or can be used to test system compatibility before loading an API into the carrier.
https://www.sciencedirect.com/topics/neuroscience/plga
Thundiparambil Azeez Sonia, Chandra P. Sharma, in Oral Delivery of Insulin, 2014. 6.5.4 Poly(lactic-co-glycolic) acid. PLGA has been the most investigated biodegradable polymer, in part due to its approval in drug formulations and medical devices by the Food and Drug Administration (FDA) and partly due to its versatility in terms of availability of different MWs, compositions and variable ...
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201701035
In this review, the physical–chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields.Author: Cláudia Martins, Flávia Sousa, Francisca Araújo, Bruno Sarmento
https://www.mdpi.com/journal/pharmaceutics/special_issues/PLGA_Pharm
Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful polymer used to produce therapeutic devices, such as drug carriers (DC). This is one of the few polymers Food and Drug Administration (FDA) approved for human administration due to its biocompatibility and biodegradability.
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