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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
The aims for nanoparticle entrapment of drugs are either enhanced delivery to, or uptake by, target cells and/or a reduction in the toxicity of the free drug to non-target organs. Both situations will result in an increase of therapeutic index, the margin between the doses resulting in a therapeutic efficacy (eg,...Author: Wim H De Jong, Paul Ja Borm
https://www.ncbi.nlm.nih.gov/pubmed/28845761
The nasal administration of drug-loaded lipid nanoparticles showed effectiveness in treating central nervous system (CNS) disorders, particularly neurodegenerative diseases, because the nasal route (also called intranasal route) allows direct nose-to-brain drug delivery by means of lipid nanoparticles.Author: S. Cunha, M. H. Amaral, J. M. Sousa Lobo, Ana C. Silva
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718451/
Dec 15, 2005 · Nanoparticle-based drug delivery systems have considerable potential for treatment of tuberculosis (TB). The important technological advantages of nanoparticles used as drug carriers are high stability, high carrier capacity, feasibility of incorporation of both hydrophilic and hydrophobic substances, and feasibility of variable routes of administration, including oral application and inhalation.Author: Svetlana Gelperina, Kevin Kisich, Michael D. Iseman, Leonid Heifets
https://www.pharmaexcipients.com/news/mucosal-nanoparticles/
Nanoparticles (NPs) often improve the efficacy of therapeutic actives, and their delivery to mucosal sites allows for unique and localized effects compared to parenteral delivery. Sites of mucosal surfaces includes the eyes, nasal cavity, lungs, and the entire gastrointestinal tract from mouth to anus, and offers extensive areas for the ...
https://www.researchgate.net/publication/340019495_Overview_of_the_Advantages_and_Disadvantages_of_Different_Mucosal_Sites_for_the_Delivery_of_Nanoparticles
In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating applications, directly targeting the central nervous system, bypassing the blood brain barrier. Its...
https://www.understandingnano.com/nanotechnology-drug-delivery.html
Nanotechnology and Nanoparticles in Drug Delivery. If your drug use consists of an occasional aspirin, you may not see the need for serious work on drug delivery. But if you were diabetic, having to inject insulin several times a day, or a cancer patient experiencing debilitating side effects from your treatment, the benefits of improved drug delivery could change your life.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386009/
Mar 31, 2015 · The advantages of particulate-based drug delivery include (1) protect the drug from enzymatic degradation, (2) evade pulmonary clearance, (3) slow the drug absorption, (4) deliver the drug to targeted site at the lungs, (5) provide a controlled drug release, (6) reduce dose frequency, (7) maximize the therapeutic efficiency, and (8) minimize adverse side effects.Author: Ibrahim M. El-Sherbiny, Nancy M. El-Baz, Magdi H. Yacoub
https://www.sciencedirect.com/science/article/pii/S1319016411000302
NLCs can generally be applied where solid nanoparticles possess advantages for the delivery of drugs. Major application areas in pharmaceutics are topical drug delivery, oral and parenteral (subcutaneous or intramuscular and intravenous) route. LDC nanoparticles have proved particularly useful for targeting water-soluble drug administration.Author: Sagar R. Mudshinge, Amol B. Deore, Sachin Patil, Chetan M. Bhalgat
https://www.azonano.com/article.aspx?ArticleID=4668
Nov 01, 2017 · Nanotechnology drug delivery applications occur through the use of designed nanomaterials as well as forming delivery systems from nanoscale molecules such as liposomes. Applying nanotechnology to drug delivery should achieve the following benefits: Improve the ability to deliver drugs that are poorly water soluble.Author: Azonano
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