Drug Delivery Modeling

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Mathematical modeling of drug delivery - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S0378517308006169
    The mathematical modeling of drug delivery has a significant potential to facilitate product development in the future and to help understanding complex pharmaceutical dosage forms. Due to the advances in information technology the accuracy of these models steadily increases and they become more and more easy to apply.Author: J. Siepmann, F. Siepmann

Modeling of diffusion controlled drug delivery - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S0168365911009588
    Mathematical modeling of drug release can be very helpful to speed up product development and to better understand the mechanisms controlling drug release from advanced delivery systems. Ideally, in silico simulations can quantitatively predict the impact of formulation and processing parameters on the resulting drug release kinetics.Author: Juergen Siepmann, Juergen Siepmann, Florence Siepmann, Florence Siepmann

Drug Delivery Systems - nibib.nih.gov

    https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
    Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are anticipated in the near future.

Mathematical modeling of drug delivery.

    https://www.ncbi.nlm.nih.gov/pubmed/18822362
    Dec 08, 2008 · Due to the significant advances in information technology mathematical modeling of drug delivery is a field of steadily increasing academic and industrial importance with an enormous future potential. The in silico optimization of novel drug delivery systems can be expected to significantly increase in accuracy and easiness of application.Author: J. Siepmann, F. Siepmann

Drug Delivery System - COMSOL Multiphysics

    https://www.comsol.com/model/drug-delivery-system-10278
    Drug Delivery System. Application ID: 10278. ... As the drop passes by the membrane, its contact angle changes and the drug dissolves into the water. To model this process a constant flux of the drug is assumed on the capillary wall for the duration of its contact with the membrane. By altering the droplet velocity, the final concentration of ...

Mathematical modeling of drug delivery - ResearchGate

    https://www.researchgate.net/publication/23285105_Mathematical_modeling_of_drug_delivery
    Due to the significant advances in information technology mathematical modeling of drug delivery is a field of steadily increasing academic and industrial importance with an enormous future...

Mathematical modeling of intraperitoneal drug delivery ...

    https://www.tandfonline.com/doi/pdf/10.1080/10717544.2016.1269848
    Simulation of drug delivery via the IP route requires a model that is similar to the description of the drug transport equations of IV delivery, but requires unique source terms in the transport equations and different boundary conditions inAuthor: Margo Steuperaert, Giuseppe Falvo D’Urso Labate, Charlotte Debbaut, Olivier De Wever, Christian Vanh...

ROLE OF MATHEMATICAL MODELLING IN CONTROLLED RELEASE …

    https://www.researchgate.net/publication/317369587_ROLE_OF_MATHEMATICAL_MODELLING_IN_CONTROLLED_RELEASE_DRUG_DELIVERY
    Peppas and B. Narasimhan, “Mathematical models i n drug delivery: How modeling has shaped the way we des ign new drug delivery systems,” J. Control. Release, vol. 190 , pp. 75– 81, 2014.

Modeling Doxorubicin Transport to Improve Intratumoral ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211420/
    Dec 04, 2007 · A mathematical model of drug transport provides an ideal strategy to optimize intratumoral drug delivery implants to supplement radiofrequency (RF) ablation for tumor treatment. To simulate doxorubicin transport in non-ablated and ablated liver tumors, a one-dimensional, cylindrically symmetric transport model was generated using a finite element method (FEM).Author: Brent D. Weinberg, Brent D. Weinberg, Ravi B. Patel, Agata A. Exner, Gerald M. Saidel, Jinming Gao

Animal Models in Drug Development - Taconic Biosciences

    https://www.taconic.com/genetically-engineered-animal-models/drug-development/
    Improving Drug Discovery Animal Models Genetically engineered mouse models play several critical roles in the drug development pipeline, including the study and characterization of disease pathology, target identification, and in vivo evaluation of novel therapeutic agents and treatments 21.

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