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http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Nose-to-Brain Mechanism of Delivery. For the purposes of drug delivery, the nasal cavity is divided into the respiratory area and the olfactory area, with the latter situated high up in the nares and the former closer to the nostrils (Sahin-Yilmaz and Naclerio, 2011).The nasal epithelium is well vascularized (Sahin-Yilmaz and Naclerio, 2011), and, within the olfactory area, olfactory neurons ...Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409749/
Feb 17, 2019 · Nose-to-brain drug delivery is a painless, non-invasive administration route that can be used to deliver therapeutic agents into the brain by bypassing the BBB [10,14,15,16,17].Author: Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovan...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199953/
May 14, 2018 · The direct nose-to-brain drug delivery offers a potential strategy for the treatment of AD. The strategy is still under investigations with various successful lab scale studies and numerous challenges to reach the pharmacy counter.Author: Amit Alexander, Shailendra Saraf
https://www.mdpi.com/1999-4923/11/2/84/pdf
Nose-to-brain drug delivery is a painless, non-invasive administration route that can be used to deliver therapeutic agents into the brain by bypassing the BBB [10,14–17]. These drug administration pathways are characterized by many advantages such as increasedAuthor: Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovan...
https://www.mdpi.com/journal/pharmaceutics/special_issues/nose_brain_delivery
Nose-to-brain delivery represents a big challenge. In fact there is a large number of neurological diseases that require therapies in which the drug must reach the brain, avoiding the difficulties due to the blood–brain barrier (BBB) and the problems connected with systemic administration, such as drug bioavailability and side-effects.
https://www.omicsonline.org/open-access/nose-to-brain-drug-delivery-a-recent-update.pdf
Nose to Brain Drug Delivery: A Recent UpdateAuthor: Bappaditya Chatterjee
https://www.youtube.com/watch?v=Cuzs-lwmfEs
Feb 08, 2017 · It is direct pathway for transport of drug nose to brain by passing BBB. ... Nose to Brain Drug Delivery System Sagar Savale. ... Increasing drug delivery through the blood-brain barrier ...Author: Sagar Savale
http://www.eurekaselect.com/123425/article
The delivery of drugs to the brain via the nose-to-brain route holds great promise, on the basis of preclinical research by means of drug delivery systems such as polymeric nanoparticles and clinical data related to intranasal delivery to CNS of large molecular weight biologics administered in solution, but safety issues about toxicity on nasal ...
https://www.sciencedirect.com/science/article/abs/pii/S0168365918302682
Although, after all, such successful research claims, very few of the nose-to-brain drug delivery of anti-AD drugs have gained market approval due to lack of sufficient clinical evidence. Onzetra Xsail® is one such marketed preparations approved for IN delivery used for the treatment of a brain disorder; migraine.Author: Mukta Agrawal, Swarnlata Saraf, Shailendra Saraf, Sophia G. Antimisiaris, Mahavir Bhupal Chougule, S...
https://pharma.aptar.com/en-us/webinars/nasal-drug-delivery-journey-systemic-nose-brain.html
In 2015, the drug market for CNS was valued at $143 billion. Nasal drug delivery devices can play a role in meeting some of these unmet medical needs, and an area within drug delivery generating much attention is the possibility of treating CNS diseases by the so-called "nose-to-brain" route.
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