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https://www.intechopen.com/books/advanced-technology-for-delivering-therapeutics/introductory-chapter-drug-delivery-concepts
Drug delivery systems (DDSs) are pharmaceutical formulations or devices that help in achieving targeted delivery and/or controlled release (CR) of therapeutic agents in our body [].Following administration, the DDSs liberate the active ingredients, and subsequently, the bioactive molecules are transported across various biological barriers to reach the site of action.
https://www.sciencedirect.com/science/article/pii/S0928098700001664
To illustrate opportunities and challenges of drug targeting, further, we will consider several examples of targeted drug delivery within the cardiovascular system, since this system demonstrates a broad variety of targets that can be reached by various targeting methods. 3. Targeting of pharmaceuticals within the cardiovascular system
https://www.tandfonline.com/toc/idrt20/current
A MEDLINE-indexed journal dedicated to all aspects of drug delivery and targeting for molecular and macromolecular drugs. Special areas of interest include the design and characterization of carrier systems for both vitro and in vivo applications.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/targeted-drug-delivery
Targeted drug delivery systems have improved cancer therapy drastically over the past decade (Kwon et al., 2012).Researchers have successfully developed cost-effective anticancer drugs mostly based on liposomes (Koning et al., 2010) and polymers (Rapoport, 2007).The basic principle of the operation of a targeted drug delivery is explained in Fig. 27.3.
https://www.ncbi.nlm.nih.gov/pubmed/28202920
Cartilage-targeting drug delivery: can electrostatic interactions help? ... Current intra-articular drug delivery methods do not guarantee sufficient drug penetration into cartilage tissue to reach cell and matrix targets at the concentrations necessary to elicit the desired biological response. Here, we provide our perspective on the ...
http://www.authorstream.com/Presentation/nikitaverma1988-715330-drug-targeting/
Dec 10, 2010 · Double Targeting Drug targeting may be combined with another methodology , other than passive and active targeting for drug delivery systems. The combination is made between spatial control and temperature control of drug delivery.
https://www.ncbi.nlm.nih.gov/pubmed/30012580
A versatile drug delivery system targeting senescent cells. ... Here, we take advantage of the high lysosomal β-galactosidase activity of senescent cells to design a drug delivery system based on the encapsulation of drugs with galacto-oligosaccharides. We show that gal-encapsulated fluorophores are preferentially released within senescent ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272876/
Aug 10, 2011 · Delivery of drug carriers to the target cells can be only a part of the whole story of successful drug targeting. Some drug carriers may have to gain access to and get inside the cytoplasm of a target cell in order to release the drug at the optimum rate for pharmacological effectiveness as in the case of gene therapy or treatment with siRNA.Author: You Han Bae, Kinam Park
https://www.amazon.com/Drug-Delivery-Targeting-Pharmacists-Pharmaceutical/dp/0415271983
Advanced drug delivery and targeting can offer significant advantages to conventional drugs, such as increased efficiency, convenience, and the potential for line extensions and market expansion. An accessible and easy-to-read textbook, Drug Delivery and Targeting for Pharmacists and Pharmaceutical Scientists is the first book to provide a ...Reviews: 2
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