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https://www.slideshare.net/sagarchawan5/blood-brain-barrier-ppt
Apr 10, 2014 · Drug Delivery and the Blood-Brain Barrier The BBB is permeable to small and lipophilic (fat-loving) molecules (up to 800 atomic mass units), but larger molecules are not transported across unless there is an active transport system available • Thus this is one of the stumbling blocks for drug delivery • An additional problem is the very ...
https://www.ncbi.nlm.nih.gov/pubmed/27020469
INTRODUCTION: There are 2 misconceptions about the cerebrospinal fluid (CSF), the blood-brain barrier (BBB), and brain drug delivery, which date back to the discovery of a barrier between blood and brain over 100 years ago. Misconception 1 is that drug distribution into CSF is a measure of BBB transport.Author: William M. Pardridge
https://www.slideshare.net/ShashankSoni/brain-targeted-drug-delivery
Mar 23, 2017 · Blood-brain barrier drug targeting: the future of brain drug development. Molecular interventions, 3(2),90. 39. Begley David J., Bradbury Michael W. , Kreuter Jörg “Targeting Macromolecules to the Central Nervous System” The Blood–Brain Barrier and Drug Delivery to the CNS, Ulrich Bickel(e.d.) , 2000 by Marcel Dekker,Inc., 8. 40.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539316/
INTRODUCTION. The blood-brain barrier (BBB) is the bottleneck in brain drug development and is the single most important factor limiting the future growth of neurotherapeutics. 1 The BBB problem is illustrated in Figure 1, which is a whole body autoradiogram of a mouse sacrificed 30 min after intravenous injection of radiolabeled histamine, a small molecule of only ∼100 Da in molecular mass.
https://link.springer.com/article/10.1007%2Fs40263-016-0405-9
Jan 18, 2017 · CNS disorders are on the rise despite advancements in our understanding of their pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the blood–brain barrier (BBB), which serves as an arduous janitor to protect the brain. Many drugs are being discovered for CNS disorders, which, however fail to enter the market because of their inability to cross the BBB. …Author: Mayur M. Patel, Bhoomika M. Patel
https://www.pharmafocusasia.com/articles/blood-brain-barrier-and-cns-drug-delivery
Introduction The idea of Blood Brain Barrier (BBB) dates back to more than 100 years ago when Paul Erlich observed that by intravenous injection of certain dyes, all organs of the animal body were stained, except the brain and the spinal cord. The densely packed brain endothelial cells, are the main part of BBB which are surrounded by astrocytic end feet, lumen, and pericyte cells.
https://www.sciencedirect.com/science/article/pii/S0168365916303236
The CNS has developed a series of barriers to protect itself from invading pathogens, neurotoxic molecules and circulating blood cells. These structures with diverse degrees of permeability include the blood–cerebrospinal fluid (CSF) barrier, the blood–brain barrier (BBB), the blood–retinal barrier and the blood–spinal cord barrier .Among these, the BBB is the most extensive and exclusive.Author: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
https://www.nature.com/articles/nrd.2015.21
Jan 22, 2016 · Georgieva, J. V., Hoekstra, D. & Zuhorn, I. S. Smuggling drugs into the brain: an overview of ligands targeting transcytosis for drug delivery across the blood–brain barrier. Pharmaceutics 6 ...Author: William A. Banks
https://www.sciencedaily.com/releases/2008/10/081022073724.htm
Oct 22, 2008 · ECCO-the European CanCer Organisation. (2008, October 22). Crossing Blood-Brain Barrier: Scientists Develop Drug Delivery System For Brain Cancers, Other Diseases. ScienceDaily. Retrieved March 4 ...
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