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https://www.ncbi.nlm.nih.gov/pubmed/18754746
Drug delivery approaches to overcome bacterial resistance to beta-lactam antibiotics. Abeylath SC(1), Turos E. Author information: (1)University of South Florida, Center for Molecular Diversity in Drug Design, Discovery, and Delivery, Department of Chemistry, Tampa, FL 33620, USA.Author: Sampath C Abeylath, Edward Turos
https://www.researchgate.net/publication/23221158_Drug_delivery_approaches_to_overcome_bacterial_resistance_to_b-lactam_antibiotics
Of the progress made so far to develop approaches to overcome bacterial resistance to beta-lactams, the use of drug carriers such as liposomes and nanoparticles seems to hold significant promise ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644377/
May 03, 2013 · Based upon these resistance mechanisms, there are essentially two options to allow the continued employment of β-lactam antibiotics: 1) design new β-lactam antibiotics that are not affected by the above mentioned bacterial resistance mechanisms, or 2) combine current β-lactam antibiotics with a drug that disables the resistance mechanisms.Author: Roberta J. Worthington, Christian Melander
https://www.researchgate.net/profile/Ruxandra_Gref/publication/281552196_An_efficient_system_for_intracellular_delivery_of_beta-lactam_antibiotics_to_overcome_bacterial_resistance/links/560306d108ae460e2704bb31/An-efficient-system-for-intracellular-delivery-of-beta-lactam-antibiotics-to-overcome-bacterial-resistance.pdf
SCIENIFIC EPORTS 5:13500 OI: 10.1038srep13500 1 www.nature.comscientificreports An efficient system for intracellular delivery of beta-lactam antibiotics to overcome bacterial resistance
http://www.uptodate.com/contents/beta-lactam-antibiotics-mechanisms-of-action-and-resistance-and-adverse-effects
Jul 26, 2017 · Beta-lactam antibiotics are among the most commonly prescribed drugs, grouped together based upon a shared structural feature, the beta-lactam ring. ... MECHANISMS OF BACTERIAL RESISTANCE. Decreased penetration to the target site; Alteration of the target site; Inactivation by a bacterial enzyme ... FDA Drug Safety Communication: Cefepime and ...
http://pubs.acs.org/doi/abs/10.1021/jo400236f
In this JOCSynopsis, we summarize small molecule strategies to overcome resistance to β-lactam antibiotics. These approaches include the development of β-lactamase inhibitors and compounds that interfere with the ability of the bacteria to sense an antibiotic threat …
https://quizlet.com/34129698/2-beta-lactam-gram-positive-antibiotics-flash-cards/
Beta-Lactam & Gram Positive Antibiotics Learn with flashcards, games, and more — for free. Search. Browse. ... residue. Leads to cell lysis. Beta-lactam antibiotics only work on bacteria that are actively growing and synthesizing the cell wall. ... drug of choice for: pneumonia, streptococci, meningeococci, non beta-lactamase producing staph ...
https://www.sciencedirect.com/topics/neuroscience/beta-lactam-antibiotics
Resistance to beta-lactam antibiotics may be due to alteration of PBPs with reduced binding with a specific antibiotic, decreased ability of the antibiotic to diffuse through bacterial cell wall, or bacteria may synthesize beta-lactamases enzymes that inactivate the antibiotic by hydrolysis of beta-lactam ring. Resistance to beta-lactam ...
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