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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769721/
The Viadur delivery system (the commercial device employing the DUROS delivery technology) is designed to deliver the therapeutic peptide leuprolide acetate for 12 months. New extensions of the DUROS drug delivery concept have been developed with …Author: Catherine M. Rohloff, Thomas R. Alessi, Bing Yang, Janice Dahms, John P. Carr, Scott D. Lautenbach
http://ijpsr.com/bft-article/a-review-on-osmotic-pump-drug-delivery-system/?view=fulltext
Classification of Osmotic Drug Delivery System: Many forms of osmotic pumps are reported in the literature but, in general they can be divided in oral and implantable systems. Implantable osmotic drug delivery system: DUROS® technology: DUROS technology, as shown in figure 1, provides a bi-compartment system separated by a piston.
https://www.dragonroids.com/connetics-alza-drug-delivery/
Connetics Corporation has entered into an agreement with ALZA Corporation to develop an advanced drug delivery system for Connetics’ proprietary recombinant human relaxin drug candidate. The development work will focus on applying ALZA’s implantable drug delivery technology, or DUROS system, to expand delivery options for relaxin.
https://www.alzet.com/company/
They were initially developed for use during internal company research, and for use by some of ALZA’s collaborators working at academic institutions. It did not take long for the word to spread about the existence of a novel drug delivery system that allowed for continuous administration of test agents into laboratory animals.
http://www.authorstream.com/Presentation/pavan22raju-1931893-implants-drug-delivery-systems/
Sep 15, 2013 · DUROS TYPE PUMP DELIVERY: DUROS TYPE PUMP DELIVERY Duros implant is a miniature cylinder made from a titanium alloy, which protects and stabilizes the drug inside using ALZA proprietary formulation technology. Water enter into one end of the cylinder through a semipermeable membrane, the drug is delivered from port of the other end.
https://www.pharmacologicalsciences.us/respiratory-depression/duros-implant-technology-for-chronic-pain-treatment.html
Jul 10, 2012 · Just as ALZA Corporation's oral and transdermal technologies can improve therapy by controlling drug delivery over hours or days, the DUROS® was designed to bring the same benefits of continuous therapy for up to 1 year. DUROS® technology is the platform for an implantable drug-dispensing osmotic pump Chronogesic®.
https://ocw.mit.edu/courses/materials-science-and-engineering/3-051j-materials-for-biomedical-applications-spring-2006/lecture-notes/lecture19.pdf
Lecture 19 Drug Delivery: Controlled Release What do we mean by “controlled” release? Control of: 1. delivery rate 2. site of release/activity Need for Control drug Traditional drug delivery concen. t time from 1 level Therapeutic range administration toxic t2 longer period of dose efficacy = toxicity risk
https://investors.durect.com/news-releases/news-release-details/pharmaceutical-firm-developing-therapies-promising-new-drug
The first New Drug Application (NDA) of a DUROS® product, ALZA's Viadur(TM) for the palliative treatment of prostate cancer, was submitted in May of this year. Under the license agreement with ALZA, DURECT has exclusive rights to use ALZA's DUROS® implant technology in several fields.
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