Dna Delivery Nanoparticles

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Nanoparticles for DNA delivery - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/B9780081005576000043
    These reactions yielded high molecular weight cross-linked PEI polymeric nanoparticles capable of binding DNA effectively while on reduction with dithiothreitol, and DNA binding ability of the degraded polymers vanished. This phenomenon produced easy unpackaging of DNA complexes in intracellular compartments for nuclear uptake and transcription.Author: Manohar Mahato, Ashwani Kumar Sharma, Pradeep Kumar

Engineering Nanoparticles for Targeted Delivery of Nucleic ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197778/
    Mar 15, 2019 · Among the nanopaticles used in gene delivery carriers, the cationic polymer and lipid were the most widely used polymer for the delivery of DNA and RNA molecules.Author: Yao Xiao, Kun Shi, Ying Qu, Bingyang Chu, Zhiyong Qian

DNA nanoparticles for ophthalmic drug delivery - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S0142961217307755
    A similar type of nanoparticles for drug delivery was introduced by our group where the inorganic material is replaced by a soft matter core consisting of hydrophobic polymer units that are covalently attached to oligonucleotides to form DNA block copolymers .Author: Jan Willem de Vries, Sven Schnichels, José Hurst, Lisa Strudel, Agnieszka Gruszka, Minseok Kwak, Min...

DNA Nanoparticles and Development of DNA Delivery Vehicles ...

    https://pubs.acs.org/doi/10.1021/bi0203987
    Oct 19, 2002 · Therefore, several laboratories are involved in the development of nonviral DNA delivery vehicles. These vehicles include polyamines, polycationic lipids, and neutral polymers, capable of condensing DNA to nanoparticles with radii of 20−100 nm.Author: Veena Vijayanathan, Thresia Thomas,§,‖ and, T. J. Thomas

519. In Vivo Delivery of Nucleic Acid to the Brain Using ...

    https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)38877-3
    May 01, 2009 · Stereotactic neurosurgery was used to unilaterally inject either the acetate or the trifluoroacetate DNA nanoparticle formulation into the murine striatum. Using an in vivo imaging system (IVIS), we assessed the level of luciferase gene activity on days 3 and 7 post-delivery of the DNA nanoparticles. Following IVIS collection on day 7, brain tissue lysates were prepared and used to …

Nanoparticle-mediated gene delivery.

    https://www.ncbi.nlm.nih.gov/pubmed/19488722
    The ability to incorporate genetic materials such as plasmid DNA, RNA, and siRNA into functionalized nanoparticles with little toxicity demonstrates a new era in pharmacotherapy for delivering genes selectively to tissues and cells.Author: Sha Jin, John C. Leach, Kaiming Ye

DNA-Functionalized Metal–Organic Framework Nanoparticles ...

    https://pubs.acs.org/doi/10.1021/jacs.8b12705
    DNA-Functionalized Metal–Organic Framework Nanoparticles for Intracellular Delivery of Proteins Shunzhi Wang Department of Chemistry and the International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United StatesAuthor: Shunzhi Wang, Yijing Chen, Shuya Wang, Peng Li, Chad A. Mirkin, Omar K. Farha

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