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https://www.sciencedirect.com/science/article/pii/B9780081005576000043
These reactions yielded high molecular weight cross-linked PEI polymeric nanoparticles capable of binding DNA effectively while on reduction with dithiothreitol, and DNA binding ability of the degraded polymers vanished. This phenomenon produced easy unpackaging of DNA complexes in intracellular compartments for nuclear uptake and transcription.Author: Manohar Mahato, Ashwani Kumar Sharma, Pradeep Kumar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197778/
Mar 15, 2019 · Among the nanopaticles used in gene delivery carriers, the cationic polymer and lipid were the most widely used polymer for the delivery of DNA and RNA molecules.Author: Yao Xiao, Kun Shi, Ying Qu, Bingyang Chu, Zhiyong Qian
https://www.sciencedirect.com/science/article/pii/S0142961217307755
A similar type of nanoparticles for drug delivery was introduced by our group where the inorganic material is replaced by a soft matter core consisting of hydrophobic polymer units that are covalently attached to oligonucleotides to form DNA block copolymers .Author: Jan Willem de Vries, Sven Schnichels, José Hurst, Lisa Strudel, Agnieszka Gruszka, Minseok Kwak, Min...
https://pubs.acs.org/doi/10.1021/bi0203987
Oct 19, 2002 · Therefore, several laboratories are involved in the development of nonviral DNA delivery vehicles. These vehicles include polyamines, polycationic lipids, and neutral polymers, capable of condensing DNA to nanoparticles with radii of 20−100 nm.Author: Veena Vijayanathan, Thresia Thomas,§,‖ and, T. J. Thomas
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)38877-3
May 01, 2009 · Stereotactic neurosurgery was used to unilaterally inject either the acetate or the trifluoroacetate DNA nanoparticle formulation into the murine striatum. Using an in vivo imaging system (IVIS), we assessed the level of luciferase gene activity on days 3 and 7 post-delivery of the DNA nanoparticles. Following IVIS collection on day 7, brain tissue lysates were prepared and used to …
https://www.ncbi.nlm.nih.gov/pubmed/19488722
The ability to incorporate genetic materials such as plasmid DNA, RNA, and siRNA into functionalized nanoparticles with little toxicity demonstrates a new era in pharmacotherapy for delivering genes selectively to tissues and cells.Author: Sha Jin, John C. Leach, Kaiming Ye
https://pubs.acs.org/doi/10.1021/jacs.8b12705
DNA-Functionalized Metal–Organic Framework Nanoparticles for Intracellular Delivery of Proteins Shunzhi Wang Department of Chemistry and the International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United StatesAuthor: Shunzhi Wang, Yijing Chen, Shuya Wang, Peng Li, Chad A. Mirkin, Omar K. Farha
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