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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722627/
Although gene therapy as a treatment for disease holds great promise, progress in developing effective clinical protocols has been slow. The problem lies in the development of safe and efficient gene-delivery systems. This review will evaluate the problems and the potential solutions in this new field of medicine.
http://www.biologydiscussion.com/gene/therapy/gene-therapy-ex-vivo-and-in-vivo-gene-therapy-with-diagram/9969
The direct delivery of genes into the cells of a particular tissue is referred to as in vivo gene therapy. The ex vivo gene therapy can be applied to only selected tissues (e.g., bone marrow) whose cells can be cultured in the laboratory. The technique of ex vivo gene therapy involves the following steps (Fig.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Most adults have been exposed to the adenovirus serotypes most commonly used in gene therapy (types 2 and 5). Adenoviruses type 2 and 5 can be utilized for transferring both dividing and nondividing cells and have low host specificity so can be used for gene delivery …
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · However, gene delivery to kidney cells is inefficient. This is due, in part, to the fact that the kidney excludes molecules a... Comparison of Gene Delivery to the Kidney by Adenovirus, Adeno-Associated Virus, and Lentiviral Vectors After Intravenous and Direct Kidney Injections …Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
https://www.sciencedirect.com/science/article/pii/S0378517313010351
Theoretically, gene therapy is a simple therapeutic method depending on either replacing a distorted gene by healthy one, or completing a missing gene in order to …Author: D. Ibraheem, A. Elaissari, H. Fessi
https://www.sciencedirect.com/topics/medicine-and-dentistry/gene-therapy
Gene therapy is a novel therapeutic approach, and can be defined as “the treatment of disease by replacing, altering, or supplementing a gene that is absent or abnormal and whose absence or abnormality is responsible for disease”. Most frequently, a functional copy of the gene is inserted in the genome to overcome the deleterious effects of the faulty gene.
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