We have collected information about Diphtheria Toxin Receptor-Targeted Brain Drug Delivery for you. Follow the links to find out details on Diphtheria Toxin Receptor-Targeted Brain Drug Delivery.
https://www.sciencedirect.com/science/article/pii/S0531513105000932
Brain drug delivery is limited by the blood–brain barrier (BBB). We have newly identified the membrane-bound precursor of heparin-binding epidermal growth factor (HB-EGF), which is also known as the diphtheria toxin receptor (DTR), as a well characterized internalizing transport receptor on the BBB for the targeting of drugs to the brain.Author: Pieter J. Gaillard, Arjen Brink, Albertus G. de Boer
https://www.researchgate.net/publication/229406368_Diphteria_toxin_receptor-targeted_brain_drug_delivery
Gaillard et al. (2005) have examined the utility of CRM197, a non toxic mutant of diphtheria toxin, as a targeting vector, for drug delivery to the brain. CRM197 has been shown to endocytose after ...
https://www.sciencedirect.com/science/article/abs/pii/S0531513105000932
Brain drug delivery is limited by the blood–brain barrier (BBB). We have newly identified the membrane-bound precursor of heparin-binding epidermal growth factor (HB-EGF), which is also known as the diphtheria toxin receptor (DTR), as a well characterized internalizing transport receptor on the BBB for the targeting of drugs to the brain.Author: Pieter J. Gaillard, Arjen Brink, Albertus G. de Boer
https://esteve.org/wp-content/uploads/2018/01/138231.pdf
Abstract. Brain drug delivery is limited by the blood-brain barrier (BBB). We have newly identified the membrane-bound precursor of heparin-binding epidermal growth factor (HB-EGF), which is also known as the diphtheria toxin receptor (DTR), as a well characterized internalizing transport receptor on the BBB for the targeting of drugs to the brain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153175/
The successful delivery of targeted toxins directly into malignant brain tumors has established this route of administration as both practical and feasible. This review summarizes the characteristics of target toxins and the key findings of the important clinical studies with …Author: Yan Michael Li, Walter A. Hall
https://www.researchgate.net/publication/6121098_A_novel_opportunity_for_targeted_drug_delivery_to_the_brain
A novel opportunity for targeted drug delivery to the brain Article in Journal of Controlled Release 116(2):e60-2 · December 2006 with 26 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811048/
EGFR-targeted diphtheria toxin stimulates TRAIL killing of glioblastoma cells by depleting anti-apoptotic proteins ... TRAIL or antibodies are suitable for treatment of brain tumors because they can be administered by convection enhanced delivery, which uses the blood brain barrier to confine the ... We anticipate that combining with TRAIL ...Author: Henrick Horita, Jacqueline Thorburn, Arthur E. Frankel, Andrew Thorburn
http://www.lorentzcenter.nl/lc/web/2007/275/presentations/de%20boer.pdf
Novel approach to deliver drugs across the blood-brain barrier to the brain A(Bert).G. de Boer BBB Research Group ... therefore global brain drug delivery! Alzheimer glioma (Krewson, Brain Res. 1995) ... non-toxic mutant diphtheria toxin
https://link.springer.com/article/10.1023/A:1026246500788
Oct 01, 2003 · The authors review the preclinical and clinical results of the ligand-targeted toxin conjugate Transferrin-CRM107 (Tf-CRM107), for the treatment of malignant gliomas. Tf-CRM107 is a conjugate protein of diphtheria toxin with a point mutation (CRM107) linked by a thioester bond to human transferrin (Tf). This conjugate exhibits potent cytotoxicity in vitro against mammalian cells expressing …Author: Michael Weaver, Douglas W. Laske
https://link.springer.com/chapter/10.1007/978-3-030-06115-9_15
Mar 12, 2019 · To overcome these problems, nanomedicines which are based on noninvasive strategies are an emerging trend for brain-targeted drug delivery. The advantages of nanoparticles such as small size, lipophilicity, target specificity, and controlled delivery of drug satisfy the requisites for brain targeting.Author: Sunita Lahkar, Malay K. Das
Searching for Diphtheria Toxin Receptor-Targeted Brain Drug Delivery?
You can just click the links above. The data is collected for you.
