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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835134/
Apr 30, 2009 · The development of safe and effective systemic small interfering RNA (siRNA) delivery systems is of central importance to the therapeutic application of siRNA. Lipid and lipid-like materials are currently the most well-studied siRNA delivery systems for liver delivery, having been utilized in several animal models, including nonhuman primates.Author: Akin Akinc, Michael Goldberg, June Qin, J Robert Dorkin, Christina Gamba-Vitalo, Martin Maier, K Nar...
https://www.sciencedirect.com/science/article/pii/S1525001616317877
Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver. ... lipid-based formulations are currently the most widely validated means for systemic delivery of siRNA to the liver. 24 The liver is an important organ with a number of potential therapeutic siRNA targets—including cholesterol biosynthesis, ...Author: Akin Akinc, Michael Goldberg, June Qin, J Robert Dorkin, Christina Gamba-Vitalo, Martin Maier, K Nar...
https://www.researchgate.net/publication/24175205_Development_of_Lipidoid-siRNA_Formulations_for_Systemic_Delivery_to_the_Liver
Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver.pdf original ar ticle 872 www.moleculartherapy .org vol. 17 no. 5, 872–879 may 2009
http://europepmc.org/articles/PMC2835134
May 01, 2009 · Several delivery systems for systemic siRNA delivery have been recently described. 2,12,13,14,15,16,17,18,19,20,21,22,23 Of all the carriers, cationic, lipid-based formulations are currently the most widely validated means for systemic delivery of siRNA to the liver. 24 The liver is an important organ with a number of potential therapeutic ...
http://connection.ebscohost.com/c/articles/38593966/development-lipidoid-sirna-formulations-systemic-delivery-liver
The development of safe and effective systemic small interfering RNA (siRNA) delivery systems is of central importance to the therapeutic application of siRNA. Lipid and lipid-like materials are currently the most well-studied siRNA delivery systems for liver delivery, having been utilized in several animal models, including nonhuman primates.
https://www.sciencedirect.com/science/article/pii/S0168365914006683
1. Introduction. Recent advances in lipid nanoparticle (LNP) systems for in vivo delivery of short-interfering RNA (siRNA) have dramatically improved the potency of siRNA-mediated gene silencing and are undergoing clinical development for the treatment of hypercholesterolemia, transthyretin-mediated amyloidosis and liver cancer , , .Current LNP–siRNA formulations are optimized for activity ...Author: Sam Chen, Yuen Yi C. Tam, Paulo J.C. Lin, Alex K.K. Leung, Ying K. Tam, Pieter R. Cullis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956923/
The liver is a major organ targeted by siRNA-based therapeutics for the treatment of liver-associated diseases and delivery of siRNA to hepatocytes has been a focus of many studies. 10,11,12,13,14 Mouse models with liver-specific expression of luciferase can greatly facilitate the discovery and preclinical development of hepatic delivery ...Author: Weikang Tao, Joseph P Davide, Mingmei Cai, Guo-Jun Zhang, Victoria J South, Andrea Matter, Bruce Ng,...
https://www.researchgate.net/publication/41041519_Rational_design_of_cationic_lipids_for_siRNA_delivery
Rational design of cationic lipids for siRNA delivery. ... Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver. ... systems for liver delivery, having been utilized in ...
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