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https://www.researchgate.net/publication/40455452_Design_of_oral_insulin_delivery_systems
The overview of various strategies applied in oral insulin delivery system design denotes the significance of mucoadhesiveness whereby a prolonged retention of dosage form in intestinal tract ...
https://www.tandfonline.com/doi/abs/10.3109/10611860903302815
May 27, 2015 · The overview of various strategies applied in oral insulin delivery system design denotes the significance of mucoadhesiveness whereby a prolonged retention of dosage form in intestinal tract translates to cumulative insulin release and absorption, overcoming the intestinal transport capacity limit.Author: Tin Wui Wong
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737653/
Mar 01, 2013 · Delivery Systems for Oral Insulin Administration. To develop an adequate oral delivery system, the main-tenance of insulin biological stability in the GIT and in the enterocytes cytosol must be addressed during the formulation process.Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792528/
Emisphere Technologies are also pursuing oral delivery as such oral route of insulin delivery takes advantage of the portal-hepatic route of absorption, as insulin would be delivered to the liver, hence acting directly on hepatic glucose production in the same way of normal physiological state 63.
https://www.sciencedirect.com/science/article/pii/S0022354919303673
The viscous and elastic mucus layer is still an undesirable barrier for oral insulin delivery. To solve the problem, virus-mimicking nanosized polyelectrolyte complex (PEC) was designed and their capacity in enhancing peroral insulin absorption in combination with bifunctional material sodium dodecyl sulfate (SDS) coating was investigated.Author: Chang Liu, Huan Xu, Ying Sun, Xin Zhang, Hongbo Cheng, Shirui Mao
https://www.sciencedirect.com/science/article/pii/S0928098720300610
Evaluation of self-emulsifying drug delivery systems for oral insulin delivery using an in vitro model simulating the ... an in vitro proteolysis model with increased physiological relevance was applied to enable the optimal design of SEDDS for oral p/p drug delivery. Graphical abstract. Download : Download high-res image (176KB) Download ...Author: Jingying Liu, Cosima Hirschberg, Mathias Fanø, Huiling Mu, Anette Müllertz
https://www.onlinelibrary.wiley.com/doi/full/10.1111/jphp.12852
Nov 28, 2017 · These are all factors that favour a switch to oral delivery of therapeutic peptides such as insulin. 22. Challenges in oral delivery of insulin. The fundamental barrier to the oral delivery of proteins is the gastrointestinal tract (GIT). The GIT functions as an absorptive and protective organ.Author: Ahmed Gedawy, Jorge Martinez, Hani Al‐Salami, Crispin R. Dass
https://www.novonordisk.com/about-novo-nordisk/perspectives/the-pursuit-of-oral-insulin.html
The story of oral insulin is closely linked with the discovery of the hormone itself a century ago as well as Novo Nordisk’s own history. In fact, when the co-discoverer of the molecule Frederick Banting first gave insulin to a person with diabetes in 1921, it was administered orally – though sadly without success.
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