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https://www.nature.com/articles/nrneurol.2017.148
Dec 01, 2017 · Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in …Author: C Rinaldi, Wood Mja.
https://www.sigmaaldrich.com/technical-documents/articles/biology/antisense-oligonucleotides.html
Delivery is key: lessons learnt from developing splice-switching antisense therapies. EMBO Mol Med, 9, 545-57. Sun Y, Zhao Y, Zhao X, Lee RJ, Teng L, & Zhou C (2017). Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation. Molecules, 22, pii: E1724. Krhac Levacic A, Morys S, & Wagner E (2017).
https://www.researchgate.net/post/How_do_I_design_antisense_oligonucleotide
How do I design antisense oligonucleotide? I do some research about LncRNA, which is located in nuclear and i want to knock down the expression by transfected the antisense oligonucleotide.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2559958/
Design and Delivery of Antisense Oligonucleotides to Block microRNA Function in Cultured Drosophila and Human Cells Michael D. Horwich and Phillip D. Zamore Department of Biochemistry and Molecular Pharmacology and Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605Author: Michael D Horwich, Phillip D Zamore
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475625/
Jun 16, 2008 · The potential use of antisense and siRNA oligonucleotides as therapeutic agents has elicited a great deal of interest. However, a major issue for oligonucleotide-based therapeutics involves effective intracellular delivery of the active molecules.Author: Rudy Juliano, Md. Rowshon Alam, Vidula Dixit, Hyumin Kang
https://mct.aacrjournals.org/content/1/5/347
Mar 01, 2002 · The use of vectors in antisense drug delivery in vivo remains, at this point, a somewhat open question. In contrast to in vitro studies, all of the clinical trials with antisense oligonucleotides are carried out with naked oligonucleotides (51, 104). A delivery vehicle does not appear to be needed as endosomal/lysosomal sequestration, and lack ...Author: Nathalie Dias, C. A. Stein
https://www.bio-rad.com/en-us/applications-technologies/oligonucleotides-design-applications?ID=MOYTCO15
Antisense oligonucleotides are used to reduce levels of protein synthesis by inhibiting mRNA processing or translation. This approach is the basis of many therapies that are now in clinical trials including a range of cancer treatments. Antisense therapy is currently available for cytomegalovirus retinitis and familial hypercholesterolemia.
https://www.oligotherapeutics.org/antisense-oligonucleotides-mechanisms-of-action-and-rational-design/
Robert MacLeod. Dr. MacLeod is currently the Vice President Oncology Research and Development, and Franchise Head at Ionis Pharmaceuticals and has contributed to the discovery and development of clinical drug candidates in the several therapeutic areas including, oncology, thrombosis, inflammatory and muscle diseases.
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1440-1681.2006.04403.x
May 12, 2006 · With a better understanding of ASO design, chemical modifications of ASO, ASO delivery systems and human pharmacokinetic and pharmacodynamic profiles of ASO and numerous ASO candidates being tested in both preclinical and clinical stages for a variety of human diseases, 1, 3, 27 the prospect for ASOs to become a major therapeutic modality is ...Author: Jasmine H. P. Chan, Shuhui Lim, W. S. Fred Wong
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