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https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/dermal-drug-delivery
Dermal drug delivery: Dermal drug delivery with lipid nanoparticles is of particular interest in hair follicle diseases, in order to enhance the local bioavailability of API at their drug target. Several targets were recognized for drugs in the hair follicle.
https://www.tandfonline.com/doi/abs/10.1080/03639045.2019.1680996
The topical route of drug delivery has been used to avoid many of these effects, but not without challenges of its own. The skin acts as an impermeable barrier to most polar drug candidate and absorption across the dermal membranes is often too slow and incomplete to produce meaningful therapeutic benefit.Author: Tarique Benbow, Jacqueline Campbell
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629190/
Oct 05, 2017 · Perhaps most promising, studies have suggested that topical application of NSAIDs via gels, creams, sprays, or plasters are as effective as oral NSAIDs and yet are associated with fewer adverse side effects [1, 34–36]. This review focuses on the topical delivery of ibuprofen, 2-(4-isobutylphenyl)propanoic acid, a widely used NSAID.Author: Martin Anthony Christopher Manoukian, Christopher William Migdal, Amode Ravindra Tembhekar, Jerad Al...
https://www.sciencedirect.com/science/article/pii/S0378517300005172
The selection of non-steroidal anti-inflammatory agents for dermal delivery. ... An analysis has been conducted to show how the penetration of a selection of non-steroidal anti-inflammatory agents (NSAIDs) through the skin may be predicted. The calculations are based on physicochemical parameters that can be predicted using commercially ...Author: Jonathan Hadgraft, Jeanetta du Plessis, Colleen Goosen
https://www.ncbi.nlm.nih.gov/pubmed/29875000
OBJECTIVES: In the present review, our major aim was to explore the therapeutic potential of advanced nanocarrier systems enlisted above for transdermal delivery of NSAIDs. All literature search regarding advanced nanocarrier systems for transdermal delivery of NSAIDs …Author: Lalit Kumar, Shivani Verma, Mehakjot Singh, Tammana Chalotra, Puneet Utreja
https://www.researchgate.net/publication/299442921_Novel_formulation_approaches_for_topical_and_transdermal_delivery_of_non-steroidal_antiinflammatory_drugs
Schematic representation of the novel and conventional dermal drug delivery systems. 4.1 Conventional formulations The classical dosage forms of NSAIDs for dermal use that are commercially ...
https://www.researchgate.net/publication/315004865_Microneedle-assisted_delivery_of_NSAIDs
Microneedle-assisted delivery of NSAIDs. ... Micro-needle assisted trans-dermal delivery of LD can be an ideal choice for the therapy of parkinson’s disease for reducing off-episodes? and side ...
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1526-4637.2010.00809.x
Topical NSAIDs had no more adverse effects than placebo. Compared with oral NSAIDs, fewer patients taking topical NSAIDs had any AEs, withdrawals due to AE, and GI AEs, but significantly more patients reported local AEs such as rash, itch, and burning. There were only 4 trials of 4 week duration.Author: Simon Haroutiunian, Daniel A Drennan, Arthur G. Lipman
http://www.eurekaselect.com/162817/article
Various advanced nanocarrier systems offer several advantages like improved dermal penetration along with an extended drug release profile due to their smaller size and high surface area. Various nanocarriers explored for transdermal delivery of NSAIDs are liposomes, niosomes, ethosomes, polymeric nanoparticles (NPs), solid lipid nanoparticles ...Author: Lalit Kumar, Shivani Verma, Mehakjot Singh, Tammana Chalotra, Puneet Utreja
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/niosomes-as-carrier-in-dermal-drug-delivery
Dermal (topical) delivery defines a targeting to the pathological sites within the skin with the least systemic absorption. Drug localization in this case is a crucial issue in the treatment of dermatological problems such as skin cancer, psoriasis, alopecia and acne, where the origin of disease is located in the skin ( Brown et al., 2006 ).Author: Yahya Rahimpour, Hamed Hamishehkar
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