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https://www.researchgate.net/publication/317140606_Dendrimers_for_Ocular_Drug_Delivery
Ocular drug delivery has seen several advances in the past few decades, with respect to new drugs, improved formulations, targeted delivery, as well as exploration of new routes of drug ...
https://www.nrcresearchpress.com/doi/abs/10.1139/cjc-2017-0193
Dendrimers for ocular drug delivery. Michael G. Lancina III, a Hu Yang b. a Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA. b Department of Chemical & Life Science Engineering, Department of Pharmaceutics, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23219, USA.Author: G Lancina Michael, Hu Yang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694674/
The ideal ocular drug delivery system should be nonirritating, isotonic, biocompatible, and biodegradable. It should also prolong the release of the drug, reduce side effects, and target the desirable eye segment. Investigations of targeted drug–dendrimers for their use in different ocular diseases are discussed ahead.Author: Marina Kalomiraki, Kyriaki Thermos, Nikos A Chaniotakis
https://www.sciencedirect.com/science/article/pii/S0223523409005194
The solubility in water of these charged dendrimers depends on the generation considered: generation 0 (3 carteolol) is well soluble, whereas generation 1 (6 carteolol) and generation 2 (12 carteolol) are poorly soluble. These dendrimers have been tested in vivo, as vehicle for …Author: Grégory Spataro, Grégory Spataro, François Malecaze, Cédric-Olivier Turrin, Cédric-Olivier Turrin, V...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
The highly branched structure of dendrimers allows incorporation of wide range of drugs, hydrophobic as well as hydrophilic. In ocular drug delivery, few promising results were reported with these branched polymeric systems [4,92,93]. Poly (amidoamine) (PAMAM) dendrimers are widely employed in …Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://kundoc.com/pdf-designing-dendrimers-for-ocular-drug-delivery-.html
In this paper we report the synthesis of a new series of phosphorus-containing dendrimers, and attempts to use them for the ocular delivery of a drug to treat glaucoma [43] and ocular hypertension, which are among the most frequent and severe ocular diseases, susceptible to degenerate to blindness [44].
https://www.sciencedirect.com/science/article/abs/pii/S0223523409005194
The solubility in water of these charged dendrimers depends on the generation considered: generation 0 (3 carteolol) is well soluble, whereas generation 1 (6 carteolol) and generation 2 (12 carteolol) are poorly soluble. These dendrimers have been tested in vivo, as vehicle for …
https://www.hindawi.com/journals/tswj/2013/732340/
Dec 14, 2013 · Therefore, dendrimeric drug delivery systems are of interest in ocular drug delivery. In this review, the limitations related to eye’s unique structure, the advantages of dendrimers, and the potential applications of dendrimeric systems to ophthalmology including imaging, drug, peptide, and gene delivery will be discussed.Author: Burçin Yavuz, Sibel Bozdağ Pehlivan, Nurşen Ünlü
https://www.liebertpub.com/doi/10.1089/jop.2012.0232
Mar 13, 2013 · Dendrimers are tree-like, nanostructured polymers that have received significant attention as ocular drug delivery systems, due to their well-defined size, tailorable structure, and potentially favorable ocular biodistribution. In this review, we highlight recent developments in dendrimer-based ocular therapies for both anterior and posterior ...Author: Siva P. Kambhampati, Rangaramanujam M. Kannan
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