We have collected information about Dendrimer Delivery Oligonucleotides for you. Follow the links to find out details on Dendrimer Delivery Oligonucleotides.
https://www.researchgate.net/publication/232068799_Dendrimer_Delivery_of_Oligonucleotides
Other uses of the dendrimers are the delivery of DNA and oligonucleotides (Poxon et al., 1996), the development of targeted delivery systems, and as carriers for the delivery of drugs via the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC113155/
Nov 01, 2000 · PAMAM dendrimers are cationic polymers that have been used for the delivery of genes and oligonucleotides to cells. However, little is known about the behavior of dendrimer–nucleic acid complexes once they reach the cell interior. To pursue this issue, we prepared dendrimers conjugated with the fluorescent dye Oregon green 488.Author: Hoon Yoo, Rudolph L Juliano
https://www.nature.com/articles/3302579
Jun 30, 2005 · We have performed a long-term study into the use of a lipophilic amino-acid dendrimer to deliver an anti-vascular endothelial growth factor (VEGF) oligonucleotide (ODN-1) …Author: R J Marano, I Toth, N Wimmer, M Brankov, P E Rakoczy
https://www.ncbi.nlm.nih.gov/pubmed/10644065
RESULTS: PAMAM dendrimers formed stable complexes with oligonucleotides that had modest cytotoxicity and showed substantial delivery activity. The dose of the oligonucleotide, the charge ratio of oligonucleotide to dendrimer, and the size (generation) of the …Author: Hoon Yoo, Peter Sazani, R. L. Juliano
https://academic.oup.com/nar/article/28/21/4225/2376299
Nov 01, 2000 · PAMAM dendrimers are cationic polymers that have been used for the delivery of genes and oligonucleotides to cells. However, little is known about the behavior of dendrimer–nucleic acid complexes once they reach the cell interior. To pursue this issue, we prepared dendrimers conjugated with the fluorescent dye Oregon green 488.Author: Hoon Yoo, Rudolph L Juliano
https://www.sciencedirect.com/science/article/pii/S0378517317305987
Aug 30, 2017 · 1. Introduction. Gene therapy is a treatment strategy aiming at delivering nucleic acid drugs into cells and achieving medical purpose by regulating the expression of target proteins and genes (Flotte, 2007).With the well-defined anatomy as well as characteristics such as immune-privilege, the eye is an ideal organ for gene therapy (Chaum and Hatton, 2002).Author: Lingyu Tai, Lingyu Tai, Chang Liu, Kuan Jiang, Xishan Chen, Linglin Feng, Weisan Pan, Gang Wei, Weiy...
https://www.sciencedirect.com/science/article/pii/S0168365904002913
Sep 14, 2004 · A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides ... These data highlight a novel anionic dendrimer delivery system for gene silencing oligonucleotides that improved their biological stability, cellular delivery and antisense activity in cultured cancer cells. ... I.F. Uchegbu, S. AkhtarEvaluation of ...Author: Majad Hussain, Majad Hussain, Mikhail S. Shchepinov, Muhammad Sohail, Ibrahim F. Benter, Ibrahim F. ...
https://www.researchgate.net/publication/12269024_Enhanced_delivery_of_antisense_oligonucleotides_with_fluorophore-conjugated_PAMAM_dendrimers
PAMAM dendrimers are cationic polymers that have been used for the delivery of genes and oligonucleotides to cells. However, little is known about the behavior of dendrimer-nucleic acid complexes ...
https://pubs.acs.org/doi/10.1021/bc050022g
Cholesterol modified mono-, di-, and tetrameric oligonucleotides were synthesized and hybridized with antisense oligonucleotides to study their incorporation in cationic liposomes together with the influence of this dendrimeric delivery system on biological activity. Electrostatic interactions seem to play the most important role during complexation with cationic lipids. This oligonucleotide ...
https://link.springer.com/10.1007/s11095-005-8330-5
Oct 01, 2005 · PAMAM G5 dendrimer (P) was conjugated to Tat peptide (T), a cell penetrating peptide, in search of an efficient cellular delivery vehicle for antisense and siRNA oligonucleotides. PAMAM G5 dendrimer was reacted with 4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-propionic acid, sulfosuccinimidyl ester, sodium salt (BODIPY) for visualization to yield the conjugate BP. Bifunctional ...Author: Hyunmin Kang, Robert DeLong, Michael H. Fisher, Rudolph L. Juliano
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