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https://www.liebertpub.com/doi/10.1089/hum.2008.928
The ability of synthetic small interfering RNA (siRNA) to potently, but reversibly, silence genes in vivo, has made them particularly well suited as a drug therapeutic. Development of therapeutics using siRNA has advanced rapidly, with five different clinical trials ongoing and several more poised to enter the clinic in the coming years.Author: Antonin R. de Fougerolles
https://www.researchgate.net/publication/5593892_Delivery_Vehicles_for_Small_Interfering_RNA_In_Vivo
However, effective delivery of small interfering RNA (siRNA) to target cells in vivo remains a challenge for that it is prone to degradation and only lasts a few days in rapidly dividing cells.Author: Antonin de Fougerolles
https://www.liebertpub.com/doi/abs/10.1089/hum.2008.928
With the identification and sequencing of the entire human genome complete, RNAi can be harnessed to rapidly develop novel drugs against any disease target. The ability of synthetic small interfering RNA (siRNA) to potently, but reversibly, silence genes in vivo, has made them particularly well suited as a drug therapeutic. Development of ...Author: Antonin R. de Fougerolles
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
RNA interference (RNAi) is caused by small (21 − 23 bases long) single-stranded RNA molecules (small-interfering RNA; siRNA), which trigger silencing of target genes in a sequence-specific manner [1,2]. The siRNA's sequence is ‘anti-sense’ (or complementary) to a specific stretch of the messenger RNA (mRNA) transcribed by the target gene.Author: Saroj P Mathupala
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273546/
Feb 06, 2012 · SPANosomes as delivery vehicles for small interfering RNA (siRNA) ... this novel vector constitutes a promising candidate for in vivo delivery of siRNA and warrants further ... Lambert J, De Smedt SC, Buyens K, Sanders NN, Van Gele M. Ultradeformable cationic liposomes for delivery of small interfering RNA (siRNA) into human primary melanocytes ...Author: Chenguang Zhou, Yicheng Mao, Yasuro Sugimoto, Yue Zhang, Naveen Kanthamneni, Bo Yu, Robert W. Bruegg...
https://www.researchgate.net/publication/51859695_SPANosomes_as_delivery_vehicles_for_small_interfering_RNA_siRNA
The efficient delivery of siRNA (small interfering RNA) to cells while avoiding the unexpected side effects is an important prerequisite for the exploitation of the power of this excellent tool.
https://en.wikipedia.org/wiki/Small_interfering_RNA
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA non-coding RNA molecules, 20-25 base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway. It interferes with the expression of specific genes with complementary nucleotide sequences by degrading mRNA after transcription, preventing ...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · For viral RNA delivery, there has been a great deal of interest in engineering adeno-associated viruses to carry nucleic acid cargo —however, this section will focus mainly on the development of non-viral materials (Table 1). Of the non-viral RNA delivery vehicles, nanoparticles are perhaps the most studied.Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · Therapeutics based on small interfering RNA (siRNA), which in principle are able to reversibly silence any gene of interest, are under development for the …Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
https://www.sciencedirect.com/science/article/pii/S0169409X16302046
Recent progress in RNA biology has broadened the scope of therapeutic targets of RNA drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs), are rapidly degraded by RNases and filtrated in the kidney, thereby requiring a delivery vehicle …Author: Hyun Jin Kim, Ahram Kim, Kanjiro Miyata, Kazunori Kataoka
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