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https://www.sciencedirect.com/science/article/pii/S0960982205001053
Endocytic Delivery to Lysosomes Mediated by Concurrent Fusion and Kissing Events in Living Cells. Author links open overlay panel Nicholas A. Bright Matthew J. Gratian J.Paul Luzio. ... are capable of being delivered from lysosomes to hybrid intermediate compartments .Author: Nicholas A. Bright, Matthew J. Gratian, J.Paul Luzio
https://portlandpress.com/biochemsoctrans/article/37/5/1019/64404/The-delivery-of-endocytosed-cargo-to-lysosomes
Cargo is delivered from late endosomes to lysosomes by kissing and direct fusion. These processes have been studied in live cell experiments and a cell-free system. Late endosome–lysosome fusion is preceded by tethering that probably requires mammalian orthologues of the yeast HOPS (homotypic fusion and vacuole protein sorting) complex.Author: J. Paul Luzio, Michael D.J. Parkinson, Sally R. Gray, Nicholas A. Bright
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133360/
A more detailed understanding of the delivery of ferritin to lysosomes under iron-replete conditions may provide mechanistic insight into the generation of hemosiderin complexes, which are insoluble iron-rich granules located in membranous compartments that are often found under conditions of iron overload.Author: Takeshi Asano, Takeshi Asano, Masaaki Komatsu, Yuko Yamaguchi-Iwai, Fuyuki Ishikawa, Noboru Mizushim...
https://www.ncbi.nlm.nih.gov/pubmed/30997751
Earlier engineered EV-based formulations for neurodegenerative diseases and cancer are reported. Herein, the use of macrophage-derived EVs for brain delivery of a soluble lysosomal enzyme tripeptidyl peptidase-1, TPP1, to treat a lysosomal storage disorder, Neuronal Ceroid Lipofuscinoses 2 (CLN2) or Batten disease, is investigated.Author: Matthew J. Haney, Natalia L. Klyachko, Natalia L. Klyachko, Emily B. Harrison, Yuling Zhao, Alexande...
https://www.sciencedirect.com/science/article/pii/S0167488908004266
However, in proximal kidney tubule cells the lysosomal enzyme cathepsin B is delivered to lysosomes following secretion of non-mannose 6-phosphate-labelled pro-cathepsin B, that then binds to the cell surface receptor megalin, which is then internalised by clathrin mediated endocytosis . Some newly synthesised lysosomal membrane proteins, such as lysosomal acid phosphatase are also mainly …Author: Paul R. Pryor, J. Paul Luzio
https://quizlet.com/148366313/lysosomes-and-autophagy-flash-cards/
- Hydrolytic enzymes inside the lysosome 1. golgi recognizes sequence in proteins 2. marks them with an oligosaccharide tag (mannose-6-phosphate, M6P) 3. recognized by M6P receptor 4. protein delivered to lysosome NOTE: M6P receptors can "catch" hydrolases that escaped and deliver to lysosome
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