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https://pharm.ucsf.edu/desai/research/ocular-drug-delivery
Topical eye drops and intraocular injections are two methods that have been employed for decades to deliver therapeutics to the eye. However, these two methods have well-recognized limitations in terms of patient compliance, discomfort, risk of infection, and inconvenience, as well as limited therapeutic bioavailability and the need for frequent repeated administration.
https://www.sciencedirect.com/science/article/pii/S1569259005100123
Drug delivery to retina has always been a challenge to ophthalmologists. The complex physiology of the retina coupled with low blood flow makes it even more difficult. Several routes of administration including systemic, topical, intravitreal, and scleral have been attempted and have met with varying degrees of success.Author: Ashim K. Mitra, Banmeet S. Anand, Sridhar Duvvuri
https://www.ondrugdelivery.com/sustained-drug-delivery-posterior-segments-eye/
DELIVERY TO TREAT DISEASES OF THE POSTERIOR SEGMENT Diseases that occur in the back-of-eye that, potentially, can result in serious visual impairment and blindness include age-related macular degeneration (AMD), macular edema, uveitis, choroidal neovascularisation (CNV), retinitis pigmentosa, and cytomegalovirus retinitis (CMV).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
The major challenge faced by today’s pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration, especially for the treatment of anterior segment diseases. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal ...Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://medicalxpress.com/news/2019-10-advance-drug-eluting-contact-lenses-delivery.html
Oct 02, 2019 · In preclinical animal models of uveitis and macular edema—two forms of eye inflammation—the lenses safely provided sustained drug delivery …
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1755-3768.2011.02299.x
Jan 23, 2012 · There are three major barriers to topical drug delivery into eye: (i) precorneal removal of drug, because of tear fluid drainage, (ii) permeation of drug molecules through the unstirred water layer (UWL) and (iii) the membrane barriers (Loftsson et al. 2008). The tear fluid is constantly produced and drained from the eye surface at a rate of about 1.5 μl/min.Author: Thorsteinn Loftsson, Phatsawee Jansook, Einar Stefánsson
https://futurism.com/neoscope/device-treats-illness-inside-eye
Traditional eye-drop treatments only allow small amounts of the drug to be delivered to the desired location, with the rest draining into the patient’s bloodstream to be filtered out of the body.
https://www.ncbi.nlm.nih.gov/pubmed/28315447
Local ocular delivery of cyclosporine A (CsA) is the preferred method for CsA delivery as a treatment for ocular inflammatory diseases such as uveitis, corneal healing, vernal keratoconjunctivitis and …Author: Frédéric Lallemand, Mathieu Schmitt, Jean-Louis Bourges, Robert Gurny, Simon Benita, Jean-Sébastien ...
https://eye.hms.harvard.edu/topic/drug-delivery-medical-devices
We hypothesized that a drug-eluting contact lens that rests on the cornea would therefore be well-suited for delivering drugs to the eye including the retina. We developed a contact lens based dexamethasone delivery system (Dex-DS) that achieved sustained drug delivery to the retina at therapeutic levels.
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