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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033645/
Feb 14, 2020 · Each of these technologies has its own advantages and disadvantages. Although some of them have successfully reached the market, the delivery of therapeutic proteins at the right concentration to the right site of action, without provoking adverse side effects, still remains a major challenge.Author: Filippo Moncalvo, Maria Isabel Martinez Espinoza, Francesco Cellesi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857543/
PolyTherics is involved in using TheraPEG ™ technology, an innovative, patent protected approach to the PEGylation of therapeutic proteins and antibody fragments. Beyond targeted PEGylation, PolyTherics has also developed proprietary polymer-based technologies for application to large proteins.Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
https://www.nature.com/articles/s41467-018-06936-1
Oct 29, 2018 · A selective expression of anti-inflammatory therapeutic proteins by inflammatory leukocytes, located mainly in the inflamed tissue, can enable an accurate tuning of …Author: Nuphar Veiga, Meir Goldsmith, Yasmin Granot, Daniel Rosenblum, Niels Dammes, Ranit Kedmi, Srinivas R...
https://www.sciencedirect.com/science/article/pii/S0022354916326272
Past, Present, and Future Technologies for Oral Delivery of Therapeutic Proteins. Author links open overlay panel Rajesh Singh 1 Shailesh Singh 1 James W. Lillard 1 2. Show more. ... C.M. LehrBioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract.Author: Rajesh Singh, Shailesh Singh, James W. Lillard, James W. Lillard
https://www.sciencedirect.com/science/article/pii/S0022354915326241
PolyTherics is involved in using TheraPEG TM technology, an innovative, patent protected approach to the PEGylation of therapeutic proteins and antibody fragments. Beyond targeted PEGylation, PolyTherics has also developed proprietary polymer-based technologies for application to large proteins.Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
http://www.chicorporate.com/uploadedFiles/Reports/Reports/Delivery_Technologies_for_Therapeutic_Proteins/sample_protein.pdf
Delivery Technologies for Therapeutic Proteins: Assessment and Outlook One thing these technologies will not do is banish injections altogether. Especially in hospital settings and for acute therapies, we expect therapeutic proteins will continue to be injected for years to come. That said, as more protein delivery technologies gain regulatory
https://www.nature.com/articles/nbt.1733
Jan 09, 2011 · Here we investigate the therapeutic utility of chemically modified mRNA as an alternative to DNA-based gene therapy. ... can lead to systemic secretion of …Author: Michael S D Kormann, Günther Hasenpusch, Manish K Aneja, Gabriela Nica, Andreas W Flemmer, Susanne H...
https://industry.gatech.edu/technology/drug-delivery-system-therapeutic-proteins
Within the pharmaceutical industry, therapeutic proteins are growing significantly in clinical use and market share. Delivery of proteins remains a challenge, and the use of protein structures to carry or display bioactive protein is currently leading to promising applications in drug delivery, diagnostics, and novel therapeutic treatments of disease.
http://www.pharmtech.com/advances-delivering-protein-and-peptide-therapeutics
Nov 02, 2016 · Noninvasive delivery. With respect to the delivery route, parenteral administration, such as intravenous, subcutaneous, and intramuscular, is the …
http://www.eurekaselect.com/56534/article
A safe, effective and patient friendly delivery of these agents is the key to commercial success. Currently, most of therapeutic proteins are administered by the parenteral route which has many drawbacks. Various delivery strategies and specialized companies have evolved over the past few years to improve delivery of proteins and peptides.
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