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https://www.ncbi.nlm.nih.gov/pubmed/14720074
However, the application of gene therapy for the treatment of pulmonary disease has been handicapped by various barriers to the delivery vectors such as serum proteins during intravenous delivery, and surfactant proteins and mucus in the airway lumen during topical application of therapeutic genes.Author: Ajay Gautam, Clifford J. Waldrep, Charles L. Densmore
https://link.springer.com/article/10.1007/BF03257161
Sep 08, 2012 · Delivery Systems for Pulmonary Gene Therapy. Abstract. Delivery of therapeutic genes to the lungs is an attractive strategy to correct a variety of pulmonary dysfunctions such as cystic fibrosis, alpha-1 antitrypsin deficiency, pulmonary hypertension, asthma, and lung cancer.Author: Ajay Gautam, Clifford J. Waldrep, Charles L. Densmore
https://www.researchgate.net/publication/8477406_Delivery_Systems_for_Pulmonary_Gene_Therapy
However, the application of gene therapy for the treatment of pulmonary disease has been handicapped by various barriers to the delivery vectors such as serum proteins during intravenous delivery ...
https://uoftmedicalgenomics.home.blog/2020/04/02/a-novel-delivery-system-for-cancer-targeted-gene-therapy/
Apr 02, 2020 · Angela Shaw Development of a novel highly efficient and selective tumor targeted delivery system to inhibit pulmonary metastasis of melanoma provides promising results. Figure 1. An illustration of (I) construction gene delivery system using r-lp, (II) targeted therapy of R-LP/sheIF3i to melanoma in lungs. (Figure from 5) As ozone levels are depleted, the atmosphere begins…
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722627/
Another means of using bacteria for gene therapy is the so-called Alternative gene therapy (AGT) approach, which is also known as bacterial protein delivery. It is based on the transfer of bacterially expressed therapeutic proteins to the host organism using genetically modified (transformed) bacteria.
https://www.ncbi.nlm.nih.gov/pubmed/28270008
Gene delivery to the lungs: pulmonary gene therapy for cystic fibrosis. Villate-Beitia I(1)(2), Zarate J(1)(2), Puras G(1)(2), Pedraz JL(1)(2). Author information: (1)a NanoBioCel Group, University of the Basque Country (UPV/EHU) , Vitoria-Gasteiz , Spain.Author: Ilia Villate-Beitia, Jon Zarate, Gustavo Puras, José Luis Pedraz
https://journal.chestnet.org/article/S0012-3692(15)38243-X/fulltext
Gene therapy for pulmonary disease has attracted a great deal ofattention since the first report of successful gene delivery 10 yearsago. Potential indications for gene therapy include chronic illnessessuch as cystic fibrosis and α 1-antitrypsin deficiency, and acute illnesses such as acute transplant rejection andchemotherapy-induced lung injury. The key technological impediment …Author: James West, David M. Rodman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814977/
The selection of (1) the appropriate transgene to modulate the selected molecular target, (2) vector type for any given transgene, (3) delivery approach, (4) dose, and (5) supporting clinical armamentarium as a whole system is the greatest predictor of successful cardiac gene therapy.Author: Michael G. Katz, Anthony S. Fargnoli, Richard D. Williams, Charles R. Bridges
https://grants.nih.gov/grants/guide/notice-files/not96-229.html
Somatic gene therapy entails two critical steps: delivery of the gene to the appropriate cells and its subsequent maintenance and expression. In order to deliver the gene to the appropriate cell, there must be a vehicle, or vector that will enter the cell and transfer the genetic material into the host genome without adverse effects.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751352/
The lung represents an attractive target for delivering gene therapy to achieve local and potentially systemic delivery of gene products. The objective of this study was to evaluate the feasibility of the AERx Pulmonary Delivery System for delivering nonviral gene therapy formulations to the lung.Author: Deepa Deshpande, James Blanchard, Sudarshan Srinivasan, Dallas Fairbanks, Jun Fujimoto, Teiji Sawa, ...
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