We have collected information about Delivery Sirna Nanoparticles for you. Follow the links to find out details on Delivery Sirna Nanoparticles.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939975/
Jul 05, 2016 · This siRNA-based revolutionary approach can soon come to the market, depending on the results of several active Phase III clinical trials.5,6 This review will focus on siRNA delivery by lipid nanoparticles (LNPs) and the current status of clinical trials for these systems. In the first section, we will describe the different components forming ...Author: Timofei S Zatsepin, Yuri V Kotelevtsev, Victor Koteliansky
https://www.sciencedirect.com/science/article/pii/S0378517317302880
Polymeric nanoparticles for siRNA delivery: Production and applications ... A summary of main molecules grafted on INU backbone to synthesize derivatives for the realization of nanoparticles for siRNA delivery is reported in Table 1. Table 1. Summary of main molecules grafted on INU backbone to synthesize derivatives for the realization of ...Author: Gennara Cavallaro, Carla Sardo, Emanuela Fabiola Craparo, Barbara Porsio, Gaetano Giammona
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964096/
Mar 18, 2014 · The safe, selective, and efficient delivery of siRNA is a key challenge to the broad application of siRNA therapeutics in humans. Motivated by the structure of lipoproteins, we developed lipopeptide nanomaterials for siRNA delivery. In vivo in mice, siRNA–lipopeptide ...Author: Yizhou Dong, Yizhou Dong, Kevin T. Love, Kevin T. Love, J. Robert Dorkin, Sasilada Sirirungruang, Yu...
https://www.sciencedirect.com/science/article/pii/S0142961215005815
However, local delivery of nanoparticle-based siRNA delivery system has not been attempted for treatment of dermal fibrotic diseases such as scleroderma. We demonstrate, for the first time, a nanoparticle platform capable of delivering siRNA with intrinsic antioxidant properties for treating fibrosis.Author: Jingga Morry, Worapol Ngamcherdtrakul, Shenda Gu, Shaun M. Goodyear, David J. Castro, Moataz M. Reda...
https://pubs.acs.org/doi/10.1021/nn502125h
Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. Journal of Controlled Release 2019, 295, 268-277. DOI: 10.1016/j.jconrel.2019.01.006. Dian-Jang Lee, Ernst Wagner.Author: Hyun Jin Kim, Hiroyasu Takemoto, Yu Yi, Meng Zheng, Yoshinori Maeda, Hiroyuki Chaya, Kotaro Hayashi,...
https://www.nature.com/articles/nnano.2012.73
However, conventional delivery nanoparticles such as liposomes and polymeric systems are heterogeneous in size, composition and surface chemistry, and this can lead to suboptimal performance, a ...Author: Hyukjin Lee, Hyukjin Lee, Abigail K. R. Lytton-Jean, Yi Chen, Kevin T. Love, Angela I. Park, Emmanou...
https://pubs.acs.org/doi/10.1021/mp300193f
Nanoparticles for Targeting Intratumoral Hypoxia: Exploiting a Potential Weakness of Glioblastoma. Pharmaceutical Research 2016, 33 (9) , 2059-2077. DOI: 10.1007/s11095-016-1947-8. So Jin Lee, Min Ju Kim, Ick Chan Kwon, Thomas M. Roberts. Delivery strategies and potential targets for siRNA in …Author: Xi-Qiu Liu, Meng-Hua Xiong, Xiao-Ting Shu, Rui-Zhi Tang, Jun Wang
https://iopscience.iop.org/article/10.1088/1361-6528/ab313d
Jul 29, 2019 · The delivery of siRNA using polymeric-based nanoparticles (e.g. PEI) can exhibit severe toxicity towards different cell lines. It was found that the increasing the number of cationic groups or the concentration of the delivery system increased the toxicity level.Author: Waleed M. Hussein, Waleed M. Hussein, Yee S. Cheong, Chang Liu, Genan Liu, Anjuman Ara Begum, Maria ...
https://www.medscape.com/viewarticle/818963
Oct 25, 2019 · This review discusses the hurdles of systemic siRNA delivery and highlights the recent progress made in lipid-based nanoparticles, which are categorized based on their key lipid components ...
https://www.hindawi.com/journals/bmri/2013/782041/
Important progress in nanotechnology has led to the development of efficient siRNA delivery systems. In this review, the authors discuss recent advances in nanoparticle-mediated siRNA delivery and the application of siRNA in clinical trials for cancer therapy. This review will also offer perspectives on future applications of siRNA therapeutics.Author: Jong-Min Lee, Tae-Jong Yoon, Young-Seok Cho
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