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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
Aptamers are a class of therapeutic oligonucleotides that form specific three-dimensional structures that are dictated by their sequences. They are typically generated by an iterative screening process of complex nucleic acid libraries employing a process termed Systemic Evolution of Ligands by Exponential Enrichment (SELEX).Author: Partha Ray, Rebekah R. White
https://www.nature.com/articles/nrd.2016.199
Nov 03, 2016 · Zhou, J. et al. Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells.Author: Jiehua Zhou, John Rossi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
Aptamers as delivery agents. Aptamers can be designed as targeting ligands, particularly when generated by cell-based SELEX, and can differentiate diseased cells from healthy cells, thus enabling the selective delivery of therapeutic compounds to target cells (Table 1).Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.ddw-online.com/therapeutics/p322575-current-trends-in-rna-therapeutics-development.html
New in vivo RNA delivery technologies including LNP or PNP systems and the use of aptamer or antibody conjugation have overcome some of the challenges associated with delivery of RNA-based therapeutics, with the selection of the delivery system depending on the therapeutics properties, type of target cell and desired delivery route.
https://www.basepairbio.com/what-is-an-aptamer/
Structure of aptamer developed by Base Pair Biotechnologies to IL-7 What is an Aptamer? The term “Aptamer” was coined by Andy Ellington. It stems from the Latin terms “aptus,” meaning to fit, and “meros,” meaning part.
https://www.sciencedirect.com/science/article/pii/S0167779911001132
Aptamers can be designed as targeting ligands, particularly when generated by cell-based SELEX, and can differentiate diseased cells from healthy cells, thus enabling the selective delivery of therapeutic compounds to target cells ().Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.researchgate.net/publication/337179618_Aptamer_Apt_System_for_Target-Specific_Drug_Delivery
Request PDF Aptamer: Apt System for Target-Specific Drug Delivery The delivery and binding of the therapeutic molecules like drugs, siRNAs and toxins to their specific target is a challenging ...
https://www.sciencedirect.com/science/article/pii/S0167779908001534
As a solution, aptamers have a radius of gyration of only a few nanometers and can therefore impart cell or tissue selectivity while they contribute little to the overall size of a drug delivery device. In addition, aptamers can be synthesized chemically (unlike antibodies) and this makes it relatively simple to attach functional groups to ...Author: Etgar Levy-Nissenbaum, Etgar Levy-Nissenbaum, Aleksandar F. Radovic-Moreno, Andrew Z. Wang, Andrew Z...
https://www.basepairbio.com/therapeutic-aptamers/
Aptamers for Protection Against Acute Stroke. Toll-like receptor 4 (TLR4) is a key player in the adaptive immune response. It is involved in several pathologies including stroke, myocardial infarction, atherosclerosis, sepsis, multiple sclerosis, and chronic pain.
https://www.raybiotech.com/custom-aptamer-services/
Now aptamers are developed using both RNA and DNA, as well as non-natural bases, backbones, and small molecules. Aptamers have been used in a variety of applications; detection molecules in ELISA-like assays, protein-specific tissue staining, targeted drug delivery, and as an FDA-approved treatment for macular degeneration 2.
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