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https://www.ncbi.nlm.nih.gov/pubmed/21369712
Enhancement techniques such as chemical enhancers, iontophoresis, microneedles, electroporation, sonophoresis, thermal ablation, laser ablation, radiofrequency ablation and noninvasive jet injectors aid in the delivery of proteins by overcoming the skin barrier in different ways.Author: Haripriya Kalluri, Ajay K. Banga
https://www.mdpi.com/2077-0383/9/2/542
The growing demand for patient-compliance therapies in recent years has led to the development of transdermal drug delivery, which possesses several advantages compared with conventional methods. Delivering protein through the skin by transdermal patches is extremely difficult due to the presence of the stratum corneum which restricts the application to lipophilic drugs with relatively low ...Author: Rezvan Jamaledin, Concetta Di Natale, Valentina Onesto, Zahra Baghban Taraghdari, Ehsan Nazarzadeh Z...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870705/
May 18, 2016 · Skin, being the largest organ of the body, is an important site for drug administration. However, most of the drugs have poor permeability and thus drug delivery through the skin is very challenging. In this study, we examined the transdermal delivery ...Author: Ankur Gautam, Jagpreet Singh Nanda, Jesse S. Samuel, Manisha Kumari, Priyanka Priyanka, Gursimran Be...
https://www.sciencedirect.com/science/article/pii/S0169409X18300231
Transdermal drug delivery offers a clinical superiority over traditional, invasive injections. As compared to oral delivery, protein drug transportation across the skin avoids the hepatic first-pass extraction and is delivered to the systematic circulation at a pharmacologically relevant rate [1,2].Author: Yanqi Ye, Jicheng Yu, Di Wen, Anna R. Kahkoska, Zhen Gu
https://segura.pratt.duke.edu/research/protein-delivery
The delivery of proteins has been widely explored to promote vascularization and tissue repair because of their ability to initiate pro-angiogenic and pro-repair signaling cascades. The Segura Laboratory has explored the delivery of growth factors in both a nanoencapsulated and a tethered approach.
https://www.sciencedirect.com/book/9780123849359/peptide-and-protein-delivery
The passive delivery of proteins through the skin has to date been impracticable due to their macromolecular and hydrophilic nature, which limits their transport through the lipophilic skin barrier (stratum corneum). Hence, several enhancement techniques have been investigated to assist delivery of these molecules through skin.
https://onlinelibrary.wiley.com/doi/pdf/10.1002/adhm.201601411
Transdermal delivery of peptides and other biological macromolecules is limited due to skin’s inherent low permeability. Here, the authors report the use of a deep eutectic solvent, choline and geranate (CAGE), to enhance topical delivery of proteins such as bovine serum albumin (BSA, molecularAuthor: Amrita Banerjee, Kelly Ibsen, Yasunori Iwao, Michael Zakrewsky, Samir Mitragotri
https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(98)01238-4
Oct 01, 1998 · Although transdermal drug delivery has many potential advantages, the permeability of skin to macromolecules is extremely low. However, the application of short, high-voltage pulses to electroporate skin has recently been shown to make it reversibly permeable. A number of studies have demonstrated that electroporation-mediated transdermal delivery of peptides, polysaccharides, …Author: Ajay K Banga, Mark R Prausnitz
https://www.nih.gov/news-events/nih-research-matters/bone-building-protein-delivered-orally-mice-using-plants
The stored IGF-1 stimulated growth and maturation in skin and bone cell lines derived from both mice and humans. When the researchers fed the powder to mice, it boosted levels of IGF-1 in the bloodstream by about 2- to 3-fold on average. Increased amounts of the protein were also found in muscle tissue.
http://www.intelon.org/publications/YangBM2012.pdf
been limited mostly to the delivery of small molecules with a charge. Ultrasound disrupts the lipid structure of stratum cor-neum to enhance the skin permeability, which may cause deep tissue damages in some cases [11,12]. Currently, there are few reports on the ef!cient transdermal delivery systems of protein drugs. * Corresponding author.
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