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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Designing and formulating a protein and peptide drug for delivery though GI tract requires a multitude of strategies. The dosage form must initially stabilize the drug making it easy to take orally 4. It must then protect the drug from the extreme acidity and action of pepsin in the stomach.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
Oral delivery is the preferred route of drug administration, as the majority of patients see it as the most convenient way to take their drugs . Drugs taken by the oral route have the highest level of patient compliance due to the ease and simplicity of taking medications [ 11 , 12 ].Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://link.springer.com/content/pdf/10.1208%2Fs12249-019-1325-z.pdf
protein polypeptide drug. BARRIERS TO ORAL DELIVERY OF PROTEIN AND PEPTIDE DRUG NPS Most of the protein and peptide drugs are macromolec-ular hydrophilic, in the extreme environment of gastrointes-tinal stability, susceptible to gastric acid and pepsin degradation; at the same time, because of its hydrophilicity,Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
http://www.pharmtech.com/considering-protein-and-peptide-delivery
Jan 02, 2019 · Drug delivery challenges posed by protein and peptide therapeutics are many. Not only are the molecules large in size but they are hydrophilic, cannot easily cross biological barriers, are degraded by enzymes, rapidly leave the circulation system, and are highly charged, all of which complicate the delivery strategy.
http://rjptonline.org/AbstractView.aspx?PID=2019-12-3-69
The present review briefly describes the possible methods for the delivery of protein and peptide drugs through various routes. KEYWORDS: Protein, Peptide, Drug delivery, Liposomes, Microparticles, Buccal delivery. Cite: L. Srinivas, V. Manikanta, M. Jaswitha. Protein and Peptide Drug Delivery - …Author: L. Srinivas, V. Manikanta, M. Jaswitha
https://link.springer.com/chapter/10.1007%2F978-3-642-59990-3_3
The use of proteins as drugs is by no means new. Insulin, gamma-globulin and protein-containing vaccines have been routinely employed for decades. However, the advent of …Author: C. R. Middaugh, R. Pearlman
http://www.authorstream.com/Presentation/pharmawick-1969759-protein-peptide-drug-delivery/
Oct 24, 2013 · SEMINAR ON PROTEIN AND PEPTIDE DRUG DELIVERY: SEMINAR ON PROTEIN AND PEPTIDE DRUG DELIVERY By M.NAGESHWAR RAO, M. Pharmacy , I YEAR II SEM Under the guidance of M.Vijayalaxmi, M. Pharm.( Ph.D ) Assistant professor , TEEGALA.KRISHNAREDDY COLLEGE OF PHARMACY, SAROOR NAGAR, HYDERABAD, 506009 1
https://www.sciencedirect.com/book/9780123849359/peptide-and-protein-delivery
While many limitations still exist regarding the cerebral delivery of peptide and protein drugs, several strategies show considerable promise for improvement of brain uptake. The chapter reviews the various strategies that are applicable for enhancing the delivery of protein/peptide delivery to the CNS.
https://www.sciencedirect.com/science/article/pii/S016836590600201X
In the design of oral delivery of peptide or protein drugs, pH sensitive hydrogels like alginate and chitosan have attracted increasing attention, since most of the synthetic polymers are immunogenic and the incorporation of proteins in to these polymers require harsh environment which may denature and inactivate the desired protein.Author: Meera George, T. Emilia Abraham
https://www.researchgate.net/publication/284171142_Nanostructures_for_protein_drug_delivery
We further classified and discussed the entries according to protein function, drug delivery, route of administration and types of excipient (freeze-dried forms). In addition, alternative choices ...
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