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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096447/
Dec 03, 2007 · Delivery systems designed to favorably alter the pharmacokinetics and biodistribution of siRNAs are essential for systemic use, as they prolong siRNA half-lives in serum and blood and reduce the effective dose of naked siRNA.Author: Saghir Akhtar, Ibrahim F. Benter
https://link.springer.com/protocol/10.1007/978-1-60761-657-3_6
Feb 08, 2010 · Systemic Delivery of Synthetic siRNAs. Abstract. RNA interference is a biological process for gene silencing that can be harnessed for the development of new drugs. However, a major obstacle to the use of small interfering RNAs (siRNAs) as therapeutics is their delivery across the plasma membrane of cells in vivo.Author: Dag R. Sørensen, Mouldy Sioud
https://link.springer.com/protocol/10.1385/1-59259-746-7:515
This is now driven predominantly by small interfering RNAs (siRNAs) as they induce sequence-specific gene silencing. However, the major obstacle to the use of siRNAs as therapeutics is the difficulty involved in effective in vivo delivery. This chapter describes the liposomal delivery of siRNAs …Author: Dag R. Sørensen, Mouldy Sioud
https://www.ncbi.nlm.nih.gov/pubmed/20387144
However, a major obstacle to the use of small interfering RNAs (siRNAs) as therapeutics is their delivery across the plasma membrane of cells in vivo. A range of solutions for this challenge have been described, including cationic lipids, high-pressure injection, viral vectors, and …Author: Dag R. Sørensen, Mouldy Sioud
https://www.researchgate.net/publication/5367981_Systemic_Delivery_of_Synthetic_siRNAs
Delivery of siRNAs has been achieved by electroporation directly into various organs and tissues of rodents. 93 In addition, topical gels 94 and lipid-based strategies 95 are among the approaches...
https://www.sciencedirect.com/science/article/pii/S0022283603001815
In mammalian cells, RNA duplexes of 21–23 nucleotides, known as small interfering RNAs (siRNAs) specifically inhibit gene expression in vitro. Here, we show that systemic delivery of siRNAs can inhibited exogenous and endogenous gene expression in adult mice.Author: Dag R. Sørensen, Marianne Leirdal, Mouldy Sioud
https://training.institut-curie.org/sites/default/files/2019-11/WEB_2020_03_JOHANNES.pdf
the delivery of therapeutic siRNAs which are designed to block immunosuppressive mechanisms. For this, the major limiting step in siRNA delivery, i.e. endosomal escape to reach the cytosol, must be overcome. Of note, STxB has an intrinsic endosomal escape capability, and the current project
https://dm5migu4zj3pb.cloudfront.net/manuscripts/33000/33494/cache/33494.1-20150304094708-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf
Nonviral delivery of synthetic siRNAs in vivo Saghir Akhtar1,2 and Ibrahim F. Benter2 1SA Pharma, Sutton Coldfield, West Midlands, United Kingdom. 2Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University Health Sciences Center, Safat, Kuwait.
https://www.jci.org/articles/view/33494
Delivery systems designed to favorably alter the pharmacokinetics and biodistribution of siRNAs are essential for systemic use, as they prolong siRNA half-lives in serum and blood and reduce the effective dose of naked siRNA.
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Among these clinical trials, most siRNAs were administered by local delivery, typically via the intravitreal or intranasal routes. However, local delivery may not be appropriate for all diseases. Under some circumstances, systemic drug administration by intravenous (i.v.) injection is needed, and delivery systems will be necessary to administer the siRNA payload.Author: Cong-fei Xu, Jun Wang
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