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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2522266/
While protein growth factors promote therapeutic angiogenesis, delivery of lipid factors such as sphingosine 1-phosphate (S1P) may provide better stabilization of newly formed vessels. We developed a biomaterial for the controlled delivery of S1P, a bioactive lipid released from activated platelets.
https://www.ncbi.nlm.nih.gov/pubmed/16602758
While protein growth factors promote therapeutic angiogenesis, delivery of lipid factors such as sphingosine 1-phosphate (S1P) may provide better stabilization of newly formed vessels. We developed a biomaterial for the controlled delivery of S1P, a bioactive lipid released from activated platelets.Author: Bradley K. Wacker, Evan A. Scott, Megan M. Kaneda, Shannon K. Alford, Donald L. Elbert
https://www.researchgate.net/publication/7176686_Delivery_of_Sphingosine_1-Phosphate_from_Polyethylene_glycol_Hydrogels
Sphingosine 1-phosphate (S1P) is a potent chemokinetic agent for endothelial cells that is released by activated platelets. We previously developed Arg-Gly-Asp (RGD)-containing polyethylene glycol...
http://europepmc.org/articles/PMC2522266
Apr 01, 2006 · While protein growth factors promote therapeutic angiogenesis, delivery of lipid factors such as sphingosine 1-phosphate (S1P) may provide better stabilization of newly formed vessels. We developed a biomaterial for the controlled delivery of S1P, a bioactive ...
https://www.sciencedirect.com/science/article/abs/pii/S0006349508707860
Endothelial Cell Migration on RGD-Peptide-Containing PEG Hydrogels in the Presence of Sphingosine 1-Phosphate ☆Author: Bradley K. Wacker, Shannon K. Alford, Evan A. Scott, Meghna Das Thakur, Gregory D. Longmore, Donald ...
https://www.scholars.northwestern.edu/en/publications/endothelial-cell-migration-on-rgd-peptide-containing-peg-hydrogel
Sphingosine 1-phosphate (S1P) is a potent chemokinetic agent for endothelial cells that is released by activated platelets. We previously developed Arg-Gly-Asp (RGD)-containing polyethylene glycol biomaterials for the controlled delivery of S1P to promote endothelialization.Author: Bradley K. Wacker, Shannon K. Alford, Evan A. Scott, Meghna Das Thakur, Gregory D. Longmore, Donald ...
https://www.cell.com/biophysj/fulltext/S0006-3495(08)70786-0
Jan 01, 2008 · Sphingosine 1-phosphate (S1P) is a potent chemokinetic agent for endothelial cells that is released by activated platelets. We previously developed Arg-Gly-Asp (RGD)-containing polyethylene glycol biomaterials for the controlled delivery of S1P to promote endothelialization.Author: Bradley K. Wacker, Shannon K. Alford, Evan A. Scott, Meghna Das Thakur, Gregory D. Longmore, Donald ...
https://link.springer.com/article/10.1007/s10439-016-1768-2
Nov 30, 2016 · Sphingosine-1-phosphate (S1P), a bioactive lipid, is a potent candidate for treatment of ischemic vascular disease. However, designing biomaterial systems Thus, the objective of this study was to design a hydrogel system that provides controlled and sustained release of S1P to establish local concentration gradients that promote neovascularization.Author: Priscilla A. Williams, Kevin T. Campbell, Hessam Gharaviram, Justin L. Madrigal, Eduardo A. Silva
https://www.researchgate.net/publication/6013740_Endothelial_Cell_Migration_on_RGD-Peptide-Containing_PEG_Hydrogels_in_the_Presence_of_Sphingosine_1-Phosphate
Sphingosine 1-phosphate (S1P) is a potent chemokinetic agent for endothelial cells that is released by activated platelets. We previously developed Arg-Gly-Asp (RGD)-containing polyethylene glycol...
https://www.sigmaaldrich.com/technical-documents/articles/material-matters/degradable-polyethylene-glycol-hydrogels.html
PEG. Poly(ethylene glycol) is a hydrophilic polymer that, when cross-linked into networks, can have a high water content. PEG is a suitable material for biological applications because it does not generally elicit an immune response. 6 Since the 1970s, PEG has been used to modify therapeutic proteins and peptides to increase their solubility, lower their toxicity and to prolong their ...
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