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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
As a whole, protein and peptide drugs have low bioavailability when administered orally due to problematic barriers including gastrointestinal proteases, the epithelial barrier and efflux pumps. Common routes of administration for the systemic delivery of peptide and protein therapeutics are …Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023392/
Mechanism of protein drug (PD) delivery to target cells. (a) Oral delivery of bioencapsulated protein drugs: Step 1, The plant cell wall protects PDs from acids and enzymes in the stomach; Step 2, Digestion of the plant cell wall by gut microbes and release...Author: Kwang-Chul Kwon, Henry Daniell
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/protein-drug-delivery
Formulation of protein and peptide drugs, their route of administration, rate, and overall pharmacokinetic profile in the body are pivotal factors in deciding the success of protein drug delivery. Until the 1950s, the oral route of drug delivery was the most preferred, along with transport by single-cell epithelial barriers.
https://www.sciencedirect.com/book/9780123849359/peptide-and-protein-delivery
While many limitations still exist regarding the cerebral delivery of peptide and protein drugs, several strategies show considerable promise for improvement of brain uptake. The chapter reviews the various strategies that are applicable for enhancing the delivery of protein/peptide delivery to the CNS.
https://link.springer.com/content/pdf/10.1208%2Fs12249-019-1325-z.pdf
protein and peptides drugs; nanotechnology has promoted the clinical application of protein drugs in recent years (5). And the advantages of nanoparticles as protein and peptide drugs carriers are listed in Table I (1). However, nanoparti-cles are rarely given with proteins and peptide drugs, and these drugs are still in the early stage of ...Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
https://www.researchgate.net/publication/9034597_Emerging_Trends_in_Oral_Delivery_of_Peptide_and_Protein_Drugs
Most peptide and protein drugs are currently used as parenteral formulations because of their poor oral bioavailability. Development of an effective oral delivery system for these macromolecular ...
https://link.springer.com/article/10.1208/s12249-019-1325-z
May 20, 2019 · Protein and peptide drugs have many advantages, such as high bioactivity and specificity, strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of protein peptides are reviewed, including chemical modification of nanocarriers, absorption enhancers, and mucous adhesion systems.Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
https://www.researchgate.net/publication/328265448_PROTEIN_AND_PEPTIDE_DRUG_DELIVERY_SYSTEM
Protein and Peptide drug delivery system are the Novel drug Delivery System. Proteins and peptides are the most abundant components of biological cells.
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