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https://www.researchgate.net/publication/26329896_Delivery_of_Phosphorodiamidate_Morpholino_Antisense_Oligomers_in_Cancer_Cells
Delivery of Phosphorodiamidate Morpholino Antisense Oligomers in Cancer Cells Article in Methods in Molecular Biology 542:351-61 · February 2009 with 40 Reads How we measure 'reads'
https://link.springer.com/protocol/10.1007/978-1-59745-561-9_19
Feb 24, 2009 · Devi G.R. (2009) Delivery of Phosphorodiamidate Morpholino Antisense Oligomers in Cancer Cells. In: Walther W., Stein U. (eds) Gene Therapy of Cancer. Methods in Molecular Biology™ (Methods and Protocols), vol 542.Author: Gayathri R. Devi
https://www.liebertpub.com/doi/abs/10.1089/108729000421448
Jul 08, 2004 · Phosphorodiamidate morpholino oligomers (PMO) are a new generation of antisense oligomers with high specificity and efficacy. They inhibit translation of targeted mRNA by steric blockade. Different methods were evaluated for efficient delivery of PMO into the cells in culture.Author: Chandramallika Ghosh, Patrick L. Iversen
http://europepmc.org/abstract/MED/19565912
Jan 01, 2009 · Phosphorodiamidate morpholino oligomers (PMO), which have a neutral chemistry, are extensively being used as tools for selective inhibition of gene expression in cell culture models and are currently in human clinical trials.Author: Gayathri R. Devi
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(19)30096-4
Jun 07, 2019 · However, therapeutic applications of AOs remain limited, particularly because of the lack of efficient cellular delivery methods imperative for achieving efficacy. In this study, we investigated a few aminoglycosides (AGs) for their potential to improve the delivery of antisense phosphorodiamidate morpholino oligomer (PMO) both in vitro and in ...Author: Mingxing Wang, Bo Wu, Sapana N. Shah, Peijuan Lu, Qilong Lu
https://www.liebertpub.com/doi/10.1089/oli.1.1996.6.169
Jan 30, 2009 · We report a simple and effective means for delivering Morpholino antisense oligos into the cytosol of cultured anchorage-dependent animal cells. ... Delivery of Phosphorodiamidate Morpholino Antisense Oligomers in Cancer Cells. ... HIV Tat Peptide Enhances Cellular Delivery of Antisense Morpholino Oligomers. Hong M. Moulton, Michelle C. Hase ...Author: Michael Partridge, Alexandra Vincent, Paula Matthews, John Puma, David Stein, James Summerton
https://www.researchgate.net/publication/5753342_c-MYC_antisense_phosphosphorodiamidate_morpholino_oligomer_inhibits_lung_metastasis_in_a_murine_tumor_model
c-MYC amplification and overexpression has been correlated with progression and chemotherapy resistance in lung cancer. AVI-4126, a neutral antisense phosphorodiamidate morpholino oligomer (PMO ...
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/phosphorodiamidate-morpholino-oligomer-avi-4126
Phosphorodiamidate morpholino oligomer AVI-4126 binds to c-Myc mRNA and blocks its translation, which may result in the death of tumor cells overexpressing c-Myc. Differing from traditional antisense oligodeoxynucleotides (ODNs), neutrally charged PMOs are composed of subunits of nucleic acid bases linked to a synthetic backbone and, so, are ...
https://www.nature.com/articles/cgt201163
Oct 14, 2011 · The synthetic antisense phosphorodiamidate morpholino oligomers ... Delivery of phosphorodiamidate morpholino antisense oligomers in cancer cells.Author: M. A. Morse, A. Hobeika, D. Serra, Katherine Aird, M. McKinney, A. Aldrich, T. Clay, D. Mourich, H. ...
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(18)30018-0
Mar 24, 2018 · Antisense oligonucleotide (AON) therapy for Duchenne muscular dystrophy has drawn great attention in preclinical and clinical trials, but its therapeutic applications are still limited due to inefficient delivery. In this study, we investigated a few saponins for their potential to improve delivery performance of an antisense phosphorodiamidate morpholino oligomer (PMO) both in vitro and in ...Author: Mingxing Wang, Bo Wu, Sapana N. Shah, Peijuan Lu, Qilong Lu
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