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http://www.glucagon.com/oxyntomodulin.html
Delivery of oxyntomodulin into the GI tract of overweight BALB/C mice through a bacterial plasmid delivery system was associated with reduced food intake and weight gain, despite no changes in plasma OXM, as described in Bifidobacterium as an oral delivery carrier of oxyntomodulin for obesity therapy: inhibitory effects on food intake and body weight in overweight mice Int J Obes (Lond). 2010 Jan 12.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986661/
Dec 14, 2013 · Oxyntomodulin (OXM) is a peptide hormone released from the gut in post-prandial state that activates both the glucagon-like peptide-1 receptor (GLP1R) and the glucagon receptor (GCGR) resulting in superior body weight lowering to selective GLP1R agonists. OXM reduces food intake and increases energy expenditure in humans.Author: Alessandro Pocai
https://www.ncbi.nlm.nih.gov/pubmed/25853306
BACKGROUND: Oxyntomodulin (OXM1-37) is an anorectic gut-secreting peptide with a promise to treat obesity, but its needle-free delivery has yet to be successful. RESULTS: Pulmonary delivery of OXM1-37, but not its C-terminal octapeptides, caused dose-related, transient 4-6 h food intake suppression in rats.Author: Nadkarni Pp, Halquist Ms, Karnes Ht, Costanzo Rm, Sakagami M
https://www.nature.com/articles/ijo2009277
Jan 12, 2010 · A novel oral delivery system of Bifidobacterium for human OXM has been successfully established. The expression of recombinant OXM can be detected in …Author: R T Long, W S Zeng, L Y Chen, J Guo, Y Z Lin, Q S Huang, S Q Luo
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