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https://www.tandfonline.com/doi/full/10.1080/03639040701199225
The purpose of the present study is to explore a potential topical drug delivery approach using HPC hot-melt extruded films as an alternative to toxic systemic delivery systems. The work reported here addresses the release rate of itraconazole as a function of HPC molecular weight, and also correlates to the resulting thermal and mechanical properties of the HME films.Author: Stacy M. Trey, Douglas A. Wicks, Praveen K. Mididoddi, Michael A. Repka
https://www.tandfonline.com/doi/abs/10.1080/03639040701199225
The rate of itraconazole release trended directly with the degree of film hydration and inversely to the hydroxypropylcellulose molecular weight. This results from a higher degree of crystallinity of the HPC films which also changes the release kinetics from first order to …Author: Stacy M. Trey, Douglas A. Wicks, Praveen K. Mididoddi, Michael A. Repka
https://www.researchgate.net/publication/6184835_Delivery_of_Itraconazole_from_Extruded_HPC_Films
Trey et al. [121] explored itraconazole for topical treatment of onchomycosis by using hydroxypropylcellulose (HPC) hot-melt extruded films as an alternative to toxic systemic delivery …
http://europepmc.org/abstract/MED/17654021
Aug 01, 2007 · The rate of itraconazole release trended directly with the degree of film hydration and inversely to the hydroxypropylcellulose molecular weight. This results from a higher degree of crystallinity of the HPC films which also changes the release kinetics from first order to zero order as a …
https://www.researchgate.net/publication/269283359_Trans-ungual_delivery_of_itraconazole_hydrochloride_by_iontophoresis
Terbinafine permeation into and across the nail plate following various nail treatments showed similar trends in both passive and iontophoretic delivery, although the extent of drug delivery ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802146/
A polymeric film containing 100 mg itraconazole per unit (2.5 cm × 2.5 cm) have been developed using generally regarded as safe listed excipients. The pH of vaginal film was found to be slightly acidic (4.90 ± 0.04) in simulated vaginal fluid and alkaline (7.04 ± 0.07) in water.Author: Nitin B. Dobaria, A. C. Badhan, R. C. Mashru
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