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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564970/
Delivery of Intracellular-acting Biologics in Pro-Apoptotic Therapies. ... the volume of trials in this area provide added optimism that intracellular-acting biologics can be feasibly developed for clinical use. ... Benoit DSW, Hoffman AS, Stayton PS. Intracellular Delivery of a Proapoptotic Peptide via Conjugation to a RAFT Synthesized ...Author: Hongmei Li, Chris E. Nelson, Brian C. Evans, Craig L. Duvall
https://www.researchgate.net/publication/50194912_Delivery_of_Intracellular-Acting_Biologics_in_Pro-Apoptotic_Therapies
Delivery of Intracellular-Acting Biologics in Pro-Apoptotic Therapies ... a variety of classes of biologics toward this goal, including antisense oligodeoxynucleotides, small interfering RNA ...
http://www.eurekaselect.com/73598
Delivery of Intracellular-Acting Biologics in Pro-Apoptotic Therapies Author(s): Hongmei Li , Chris E. Nelson , Brian C. Evans , Craig L. Duvall .Author: Hongmei Li, Chris E. Nelson, Brian C. Evans, Craig L. Duvall
http://europepmc.org/articles/PMC3564970
Jan 01, 2011 · However, stability in the in vivo environment, tumor-specific biodistribution, cell internalization, and localization to the intracellular microenvironment where the targeted molecule is localized pose significant challenges that limit the ability to directly apply intracellular-acting, pro-apoptotic biologics for therapeutic use.
https://link.springer.com/article/10.1007/s12272-018-1038-y
May 26, 2018 · Pro-apoptotic peptides-based cancer therapies: challenges and strategies to enhance therapeutic efficacy ... Evans BC, Duvall CL (2011) Delivery of intracellular-acting biologics in pro-apoptotic therapies. Curr Pharm Des ... Liang X-J (2017) pH-sensitive polymeric micelles for the Co-delivery of proapoptotic peptide and anticancer drug for ...Author: Kyoung Ah Min, Pooja Maharjan, Songhee Ham, Meong Cheol Shin
https://www.researchgate.net/publication/40455240_Intracellular_Delivery_of_a_Proapoptotic_Peptide_via_Conjugation_to_a_RAFT_Synthesized_Endosomolytic_Polymer
Intracellular Delivery of a Proapoptotic Peptide via Conjugation to a RAFT Synthesized Endosomolytic Polymer Article in Molecular Pharmaceutics 7(2):468-76 · December 2009 with 66 Reads
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427876/
Introduction. The introduction of antibody and antibody–drug conjugate (ADC) therapeutics has had a major impact in the cancer field. 1 ADCs, in particular, have shown considerable promise in improving the delivery of potent chemotoxins to tumor lesions while limiting off-target toxicities. 2,3 Current ADCs are limited to membrane-permeable small molecule drugs, but expanding their ...
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