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https://www.michaeljfox.org/grant/intranasal-delivery-gdnf-parkinsons-disease-next-steps
GDNF, a naturally-occurring growth factor capable of protecting and promoting the survival of dopamine neurons, has great potential as a treatment for Parkinson’s disease. However, the delivery of GDNF to the brain has proven to be an insurmountable obstacle.
https://www.ncbi.nlm.nih.gov/pubmed/32059808
Feb 10, 2020 · Here, we examined whether delivery of a developmentally critical protein, glial cell line-derived neurotrophic factor (GDNF), could improve graft outcomes. We tracked the response of DAns implanted into either a GDNF-rich environment or after a delay in exposure.Author: Carlos W. Gantner, Isabelle R. de Luzy, Jessica A. Kauhausen, Niamh Moriarty, Jonathan C. Niclis, Ch...
https://www.michaeljfox.org/grant/delivery-gdnf-brain-novel-nanovesicles-treatment-pd
Objective/Rationale: GDNF has the potential to halt the progression of, or reverse, PD. However, GDNF, a large protein, does not get into the brain when given orally or intravenously. Our novel nano-sized vesicles, called V-SmartTM, encapsulate proteins, cross the blood-brain barrier and release their drug contents in the brain. We intend to customize V-SmartTM vesicles for the delivery of ...
https://medium.com/parkinsons-uk/gdnf-trial-results-explained-8366de5ee669
Feb 27, 2019 · To address this challenge, neurosurgeon Professor Steven Gill, designed a sophisticated new delivery system. Instead of a slow but constant flow of GDNF, the new delivery …Author: Claire Bale
https://www.sciencedirect.com/science/article/pii/S1934590920300102
GDNF Overexpression Temporally Regulates Downstream pERK and pS6 Signaling in Grafted Dopamine Neurons (A and B) Assessment of the host midbrain (ipsilateral and contralateral to the AAV-GDNF intrastriatal delivery) verifying the capacity to measure changes in (A) …Author: Carlos W. Gantner, Isabelle R. de Luzy, Jessica A. Kauhausen, Niamh Moriarty, Jonathan C. Niclis, Ch...
https://clinicaltrials.gov/ct2/show/NCT01621581
Jun 18, 2012 · Preliminary clinical trials of GDNF infusions have yielded inconclusive results. Observed problems with tolerability and efficacy in these studies may have been related to the methods of delivery. Recent evidence indicates that gene transfer via direct delivery of viral vectors may represent a superior approach for the treatment of PD with GDNF.
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