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https://www.liebertpub.com/doi/abs/10.1089/108729003321629647
The iontophoresis current did not cause any detectable ocular damage under these conditions. Iontophoresis promotes the delivery of ODNs to the anterior segment of the eye, including all corneal layers. Iontophoresis of ODNs directed at VEGF-R2 may be used for the design of specific antiangiogenic strategy in diseases of the cornea.Author: M Berdugo, F Valamanesh, Christophe Andrieu, C Klein, D Benezra, Y Courtois, F Behar-Cohen
https://www.researchgate.net/publication/10710679_Delivery_of_Antisense_Oligonucleotide_to_the_Cornea_by_Iontophoresis
The single-stranded antisense oligonucleotide (~7 kDa) was also reported to be effectively delivered into the cornea with iontophoresis (Berdugo et al., 2003). The results in the present study ...
https://research-information.bris.ac.uk/en/publications/delivery-of-antisense-oligonucleotide-to-the-cornea-by-iontophoresis(e5861721-1289-4af5-86d0-175e07ee710a)/export.html
title = "Delivery of antisense oligonucleotide to the cornea by iontophoresis", abstract = "We wished to evaluate the potential of iontophoresis to promote the delivery of antisense oligonucleotides (ODN) directed at the vascular endothelial growth factor (VEGF) …Author: M Berdugo, F Valamanesh, Christophe Andrieu, C Klein, D Benezra, Y Courtois, F Behar-Cohen
https://www.ncbi.nlm.nih.gov/pubmed/28375679
Dual-Phase Iontophoresis for the Delivery of Antisense Oligonucleotides. Gibson DJ(1), Tuli SS(2), Schultz GS(1). Author information: (1)1 Institute for Wound Research, University of Florida , Gainesville, Florida. (2)2 Department of Ophthalmology, University of Florida , Gainesville, Florida.Author: J GibsonDaniel, S TuliSonal, S SchultzGregory
https://www.liebertpub.com/doi/10.1089/nat.2016.0654
Aug 01, 2017 · The changes enabled delivery into ex vivo skin and corneas in 10 or fewer minutes and into in vivo corneas in 5 min. In vivo studies demonstrated short-term bioavailability of at least 24 h, a lack of chemical or thermal injury, a lack of interference in the healing of a corneal injury, and an antisense effect till at least day 7, but not day ...Author: J GibsonDaniel, S TuliSonal, S SchultzGregory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823390/
Feb 15, 2010 · This paper reviews the strategies of in vivo gene delivery to the cornea. A number of studies have demonstrated the feasibility of targeted delivery of oligonucleotides, small interfering RNA (siRNA), plasmid DNA, and viral vectors to the corneal cells in vivo, specifically stromal keratocytes and corneal epithelial cells, via intrastromal injection, iontophoresis, electroporation, and gene gun.Author: Jinsong Hao, S. Kevin Li, Winston W.Y. Kao, Chia-Yang Liu
https://www.sciencedirect.com/science/article/pii/S0169409X0600161X
Ocular delivery of nucleic acids: antisense oligonucleotides, aptamers and siRNA ... D. Benezra, Y. Courtois, F. Behar-CohenDelivery of antisense oligonucleotide to the cornea by iontophoresis. Antisense Nucleic Acid Drug Dev., 13 (2003), pp. 107-114.Author: Elias Fattal, Amélie Bochot
https://core.ac.uk/display/20047776
Abstract. We wished to evaluate the potential of iontophoresis to promote the delivery of antisense oligonucleotides (ODN) directed at the vascular endothelial growth factor (VEGF)-R2 receptor (KDR/Flk) to the cornea of the rat eye.Author: M Berdugo, F Valamanesh, Christophe Andrieu, C Klein, D Benezra, Y Courtois, F Behar-Cohen
https://www.sciencedirect.com/science/article/pii/S0361923009001932
This paper reviews the strategies of in vivo gene delivery to the cornea. A number of studies have demonstrated the feasibility of targeted delivery of oligonucleotides, small interfering RNA (siRNA), plasmid DNA, and viral vectors to the corneal cells in vivo, specifically stromal keratocytes and corneal epithelial cells, via intrastromal injection, iontophoresis, electroporation, and gene gun.Author: Jinsong Hao, S. Kevin Li, Winston W.Y. Kao, Chia-Yang Liu
https://www.oligotherapeutics.org/dual-phase-iontophoresis-delivery-antisense-oligonucleotides/
Taking oligonucleotide research to its full therapeutic potential. You are here: Home; Hot Papers; Delivery; Dual-Phase Iontophoresis for the Delivery… Dual-Phase Iontophoresis for the Delivery of Antisense Oligonucleotides ... Oligonucleotide Therapeutics Society c/o Event Innovations, Inc. 4377 Newport Avenue San Diego, CA 92107, USA Phone: ...
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