Delivery Of Antisense Oligonucleotide To The Cornea By Iontophoresis

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Delivery of Antisense Oligonucleotide to the Cornea by ...

    https://www.liebertpub.com/doi/abs/10.1089/108729003321629647
    The iontophoresis current did not cause any detectable ocular damage under these conditions. Iontophoresis promotes the delivery of ODNs to the anterior segment of the eye, including all corneal layers. Iontophoresis of ODNs directed at VEGF-R2 may be used for the design of specific antiangiogenic strategy in diseases of the cornea.Author: M Berdugo, F Valamanesh, Christophe Andrieu, C Klein, D Benezra, Y Courtois, F Behar-Cohen

Delivery of Antisense Oligonucleotide to the Cornea by ...

    https://www.researchgate.net/publication/10710679_Delivery_of_Antisense_Oligonucleotide_to_the_Cornea_by_Iontophoresis
    The single-stranded antisense oligonucleotide (~7 kDa) was also reported to be effectively delivered into the cornea with iontophoresis (Berdugo et al., 2003). The results in the present study ...

Delivery of antisense oligonucleotide to the cornea by ...

    https://research-information.bris.ac.uk/en/publications/delivery-of-antisense-oligonucleotide-to-the-cornea-by-iontophoresis(e5861721-1289-4af5-86d0-175e07ee710a)/export.html
    title = "Delivery of antisense oligonucleotide to the cornea by iontophoresis", abstract = "We wished to evaluate the potential of iontophoresis to promote the delivery of antisense oligonucleotides (ODN) directed at the vascular endothelial growth factor (VEGF) …Author: M Berdugo, F Valamanesh, Christophe Andrieu, C Klein, D Benezra, Y Courtois, F Behar-Cohen

Dual-Phase Iontophoresis for the Delivery of Antisense ...

    https://www.ncbi.nlm.nih.gov/pubmed/28375679
    Dual-Phase Iontophoresis for the Delivery of Antisense Oligonucleotides. Gibson DJ(1), Tuli SS(2), Schultz GS(1). Author information: (1)1 Institute for Wound Research, University of Florida , Gainesville, Florida. (2)2 Department of Ophthalmology, University of Florida , Gainesville, Florida.Author: J GibsonDaniel, S TuliSonal, S SchultzGregory

Dual-Phase Iontophoresis for the Delivery of Antisense ...

    https://www.liebertpub.com/doi/10.1089/nat.2016.0654
    Aug 01, 2017 · The changes enabled delivery into ex vivo skin and corneas in 10 or fewer minutes and into in vivo corneas in 5 min. In vivo studies demonstrated short-term bioavailability of at least 24 h, a lack of chemical or thermal injury, a lack of interference in the healing of a corneal injury, and an antisense effect till at least day 7, but not day ...Author: J GibsonDaniel, S TuliSonal, S SchultzGregory

Gene delivery to cornea - PubMed Central (PMC)

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823390/
    Feb 15, 2010 · This paper reviews the strategies of in vivo gene delivery to the cornea. A number of studies have demonstrated the feasibility of targeted delivery of oligonucleotides, small interfering RNA (siRNA), plasmid DNA, and viral vectors to the corneal cells in vivo, specifically stromal keratocytes and corneal epithelial cells, via intrastromal injection, iontophoresis, electroporation, and gene gun.Author: Jinsong Hao, S. Kevin Li, Winston W.Y. Kao, Chia-Yang Liu

Ocular delivery of nucleic acids: antisense ...

    https://www.sciencedirect.com/science/article/pii/S0169409X0600161X
    Ocular delivery of nucleic acids: antisense oligonucleotides, aptamers and siRNA ... D. Benezra, Y. Courtois, F. Behar-CohenDelivery of antisense oligonucleotide to the cornea by iontophoresis. Antisense Nucleic Acid Drug Dev., 13 (2003), pp. 107-114.Author: Elias Fattal, Amélie Bochot

Delivery of antisense oligonucleotide to the cornea by ...

    https://core.ac.uk/display/20047776
    Abstract. We wished to evaluate the potential of iontophoresis to promote the delivery of antisense oligonucleotides (ODN) directed at the vascular endothelial growth factor (VEGF)-R2 receptor (KDR/Flk) to the cornea of the rat eye.Author: M Berdugo, F Valamanesh, Christophe Andrieu, C Klein, D Benezra, Y Courtois, F Behar-Cohen

Gene delivery to cornea - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S0361923009001932
    This paper reviews the strategies of in vivo gene delivery to the cornea. A number of studies have demonstrated the feasibility of targeted delivery of oligonucleotides, small interfering RNA (siRNA), plasmid DNA, and viral vectors to the corneal cells in vivo, specifically stromal keratocytes and corneal epithelial cells, via intrastromal injection, iontophoresis, electroporation, and gene gun.Author: Jinsong Hao, S. Kevin Li, Winston W.Y. Kao, Chia-Yang Liu

Dual-Phase Iontophoresis for the Delivery of Antisense ...

    https://www.oligotherapeutics.org/dual-phase-iontophoresis-delivery-antisense-oligonucleotides/
    Taking oligonucleotide research to its full therapeutic potential. You are here: Home; Hot Papers; Delivery; Dual-Phase Iontophoresis for the Delivery… Dual-Phase Iontophoresis for the Delivery of Antisense Oligonucleotides ... Oligonucleotide Therapeutics Society c/o Event Innovations, Inc. 4377 Newport Avenue San Diego, CA 92107, USA Phone: ...

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