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https://www.researchgate.net/publication/334437690_Nanoemulsion_A_Review_on_Mechanisms_for_the_Transdermal_Delivery_of_Hydrophobic_and_Hydrophilic_Drugs
NE Mechanisms for Enhanced T ransdermal Delivery of Hydrophilic Drugs The mechanism by which a hydrophilic drug is transported through skin from a w / o NE, is indeed di ff erent from a ...
https://www.cell.com/trends/molecular-medicine/pdf/S1471-4914(10)00113-9.pdf
particles for the delivery of small-molecule anticancer agents and recent advances in this field. Advantages of nanoparticles for the delivery of small-molecule anticancer agents In recent years, the development of therapeutic nanopar-ticles (TNPs) for the delivery of small-molecule anticancer agents has received great attention from the ...
https://www.sciencedirect.com/science/article/pii/S0079642519300817
Drugs or NPs can move across the NPCs via both passive and active delivery. Passive delivery of cytoplasm to nucleus occurs by using ions, small molecules, and NPs of up to 9 nm . Macromolecules larger than 39 nm (40 KDa) are not capable of nuclear entry either upon the occurrence of mitosis, which makes the nuclear membrane break down, or ...
https://www.atsjournals.org/doi/full/10.1513/pats.200409-049TA
Sep 30, 2004 · The lung is naturally permeable to all small-molecule drugs studied and to many therapeutic peptides and proteins. Absorption can be estimated using a simple animal test, intratracheal instillation. Inhalation offers a noninvasive route for the delivery of peptides and proteins that otherwise must be injected.
http://www.pharmtech.com/oral-delivery-macromolecular-drugs
Macromolecular drugs are a newer class of drugs that have improved efficacy and require injection. Researchers are studying oral delivery approaches for macromolecular drugs that have better patient acceptance and adherence, more convenient dosing, and an improved therapeutic profile.
https://www.mdpi.com/1999-4923/12/2/154/pdf
Transporter-Mediated Delivery of Small Molecule Drugs to the Brain: A Critical Mechanism That Can Advance Therapeutic Development for Ischemic Stroke Erica I. Williams, Robert D. Betterton, Thomas P. Davis and Patrick T. Ronaldson * Department of Pharmacology, College of Medicine, University of Arizona, 1501 N. Campbell Avenue, P.O. Box
https://www.hindawi.com/journals/bmri/2014/869269/
More often, large molecule drugs such as recombinant neurotrophins, and neurotrophins do not cross the brain capillary endothelial wall but prove to be more effective than smaller size drugs. Hence, to make neurotrophins transportable across the BBB, chimeric peptides are made in which a neurotrophin is reformulated by fusion to a transport vector.
http://www.pharmtech.com/four-challenges-pulmonary-drug-delivery
Pulmonary drug delivery is becoming increasingly used. When developing pulmonary drugs, pharmaceutical chemists must consider drug absorption, control of particle size, suitable toxicology models, and patient compliance. The author reviews the issues specific to developing drugs designed for pulmonary delivery and considers how—with the right knowledge and expertise—these challenges …
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
REFERENCE ID: PHARMATUTOR-ART-1700 INTRODUCTION The delivery of the drug through the respiratory tract is called pulmonary drug delivery. In case of brochodialating drugs, this is advantageous as drug will deliver directly to region where its action is required so that the drug effect will be faster and low dose of drug can be administered through this delivery system and so the side …
https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2012.126
Large molecule drugs can be reengineered with molecular Trojan horse delivery systems to access receptor-mediated transport (RMT) systems within the BBB. Peptide and antisense radiopharmaceuticals are made brain-penetrating with the combined use of RMT-based delivery systems and avidin–biotin technology. Knowledge on
https://link.springer.com/10.1208/s12248-008-9055-2
Aug 26, 2008 · This section will touch on cell-penetrating peptides generally speaking and their mechanisms of internalization. From there, a selection of these peptides will be described leading to their potential use for transport of small drugs and protein-based large molecule drugs. And finally, we will see the limitations and pitfalls of the CPP approach.
http://www.adminmed.com/files/web/publications/2013_Low-Frequency_Sonophoresis_Combined_with_MNs-Das.pdf
veloped to increase the permeability of these drugs in skin. But, in the delivery of large molecules such as insulin, bovine serum albumin (BSA) or tetanus toxoid, the delivery rates of the molecule are still found to be either low or undetectable ac-cording to many literatures.4–7 Because of …
https://www.pfizer.com/science/research-development/medicinal-sciences
The Medicinal Sciences group has a central role in this endeavor, from the conception of an idea all the way through to the delivery of a new therapy to patients. Pfizer's rich and diverse pipeline includes small-molecule drugs, large-molecule biotherapeutics such as antibodies, as well cell- and gene-based therapies and vaccines. ...
https://cdn.intechopen.com/pdfs/40262/InTech-Nanotechnology_in_drug_delivery.pdf
This is because of the challenges with use of large size materials in drug delivery, some of which include poor bioavailability, in vivo stability, solubility, intestinal absorption, sustained and targeted delivery to site of action, therapeutic effectiveness, generalized side effects, and plasma fluctuations of drugs.
https://www.hindawi.com/journals/jnm/2016/1087250/
Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used both to design new nanoparticles and to better understand existing ones. Modeled processes include the release of drugs at the tumor site and the physical interaction between the nanoparticle and ...
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