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https://www.nature.com/articles/nrd1775
Jul 01, 2005 · With a growing understanding of polymer gene-delivery mechanisms, it is likely that polymer-based gene-delivery systems will become an important tool for human gene therapy.Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
https://www.amazon.com/Polymeric-Gene-Delivery-Principles-Applications/dp/084931934X
Polymeric Gene Delivery: Principles and Applications accentuates the versatility of polymeric delivery systems, including the potential for biocompatibility, the ability to design their formulation and geometry for a specific purpose, and the ease of modification to the surface of polymeric carriers.Author: Mansoor M. Amiji
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178691/
Systemic gene delivery requires the rational design of a polymeric gene vehicle with high solubility, low cytotoxicity, serum stability, efficient endosomal release, adequate protection against endonucleases, and most importantly, a high transfection efficiency and gene expression.Author: Sung Wan Kim, Sung Wan Kim
https://www.sciencedirect.com/science/article/pii/S016777991830060X
Gene delivery mediated by polymeric vectors is a multistage process. It involves multiple obstacles to overcome before the nucleic acid material can reach the target site (Figure 1, Key Figure). The target site here refers to the cytosol for RNA molecules and the nucleus for plasmids.Author: Wing-Fu Lai, Wing-Fu Lai, Wing-Tak Wong
https://www.sciencedirect.com/science/article/pii/S0168365919306108
Cationic polymers have emerged as highly attractive vehicles for gene therapy and are, by far, the most deliberated polymeric gene delivery vehicles for both non-coding RNAs and oligo-DNAs. Generally, these polymers are composed of amines that can be protonated, and which are thus capable of interacting with the non-coding RNAs and condensing them to form polyplexes, as can be seen in …Author: Anna Kargaard, Anna Kargaard, Joost P.G. Sluijter, Bert Klumperman
https://www.sciencedirect.com/science/article/pii/S0169409X06000500
Gene delivery from polymeric scaffolds has been considered as an attractive approach to overcome the drawbacks of protein delivery. Localized and sustained DNA delivery from the scaffolds can provide a long-term expression of biologically active proteins to guide the cells to form a desired tissue .Author: Tae Gwan Park, Ji Hoon Jeong, Sung Wan Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480422/
Mar 13, 2017 · Challenges in Using Polymeric Gene Delivery Systems In Vivo. The majority of gene delivery systems are cationic, and the density of this cationic charge is an important determinant of the toxicity of the nanocarrier materials.Author: Narsireddy Amreddy, Anish Babu, Ranganayaki Muralidharan, Anupama Munshi, Rajagopal Ramesh
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