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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
The major challenge faced by today’s pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration, especially for the treatment of anterior segment diseases.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.ondrugdelivery.com/topic/ocular/
USING PHYSICAL FORCES TO ENHANCE OCULAR DRUG DELIVERY . Di Huang, Erica Chen and Ilva Rupenthal discuss the possibilities offered by physical force-based methods of enhancing the efficacy of ophthalmic drug delivery by providing a way past the eye’s natural barriers. EXPERT VIEW
https://pharm.ucsf.edu/desai/research/ocular-drug-delivery
A drug delivery device capable of sustained release of biological therapeutics over several months can maintain effective therapeutic concentrations and reduce the number of injections, significantly improving ocular therapies. One attractive platform for continuous delivery of antibody-based therapeutics is the use of nanoporous materials.
https://www.healio.com/ophthalmology/cornea-external-disease/news/print/ocular-surgery-news/%7Bd69fee03-15c5-4fbd-a090-4f8a5b294c17%7D/understanding-topical-ophthalmic-drug-delivery-how-much-gets-in
Ocular Surgery News In understanding how much of an artificial tear or a prescription eye drop actually reaches its target tissue, it is helpful to appreciate the significant obstacles to drug ...
https://www.researchgate.net/publication/235924442_OCULAR_DRUG_DELIVERY_A_REVIEW
OCULAR DRUG DELIVERY: A REVIEW ... In conclusion, polymeric micelle prepared with solid dispersion using Soluplus® can be a potential nanomedicine for ocular delivery of …
https://www.arvo.org/globalassets/annual-meeting/program/education-courses/2020-agenda---ocular-drug-delivery.pdf
Ocular drug delivery is an evolving field featuring cutting-edge advances in devices, formulations, and paradigms for design and characterization. This course will draw upon experts in the various disciplines of the field in order to instruct
https://www.sciencedirect.com/topics/nursing-and-health-professions/drug-delivery-system
Ocular drug delivery and toxicology. Frederick T. Fraunfelder MD, in Clinical Ocular Toxicology, 2008. Drug delivery to the eye is a complex process. As a self-contained system, the eye is unique in the body in many ways that affect pharmacology and toxicology. It includes several different cell types, and functions as a complete, self ...
https://www.ondrugdelivery.com/modelling-ocular-delivery-using-computational-fluid-dynamics/
Computer modelling is helping pharmaceutical scientists understand the interplay between drug formulation, fluid flow and clearance, which is leading to the development of more effective ocular drug delivery systems. Classical pharmacokinetic (PK) models were among the first models developed for predicting ocular drug disposition.
https://eye.hms.harvard.edu/topic/drug-delivery-medical-devices
Nevertheless, low ocular bioavailability of topically applied drug molecules can considerably limit their efficacy. Over the last several decades, numerous drug delivery systems (DDS) have been developed in order to improve drug bioavailability on the ocular surfaces.
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