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https://www.ondrugdelivery.com/combining-human-needs-with-high-viscosity-formulations/
Citation: Bradshaw J, White S, “Combining Human Needs with High Viscosity Formulations”. ONdrugDelivery Magazine, Issue 91 (Oct 2018), pp 16-21. Jonathan Bradshaw and Susie White discuss the requirements of designing an autoinjector capable of handling the high pressures necessary for the delivery of highly viscous drug formulations with ...
https://www.ondrugdelivery.com/function-based-primary-packaging-design-for-injecting-viscous-non-newtonian-formulations/
Citation: Vilaplana M, Vasiev A, White S, “Function-Based Primary Packaging Design for Injecting Viscous Non-Newtonian Formulations”. ONdrugDelivery Magazine, Issue 101 (Oct 2019), pp 20-25. Marta Vilaplana; Alex Vasiev and Susie White explore the challenges of delivering high-viscosity, non-Newtonian fluids emphasising the importance of robust tools to characterise specific device and ...
https://www.researchgate.net/publication/300485114_Development_of_delivery_device_technology_to_deal_with_the_challenges_of_highly_viscous_mAb_formulations_at_high_concentration
The need for injection devices is discussed with an emphasis on mitigation of the technical problems of delivery of high viscosity, high concentration mAb formulations.Author: Steven J. Shire
http://www.pharmtech.com/delivering-high-concentration-protein-formulations-0
Apr 02, 2018 · High viscosity not only presents difficulties in processing and storage, but it is known to pose formulation and delivery challenges, as viscous solutions require high injection force to administer the drug and may also require prolonged injection time.
https://www.meddeviceonline.com/doc/key-usability-considerations-for-biopharmaceutical-delivery-device-design-0001
Jul 09, 2019 · Increased subjective pain during drug delivery arises due to two factors: 1) hand tremors caused by high drug device activation forces and 2) extended injection times as a function of increased viscosity of the drug (more on injection time in a moment).Location: 5 Walnut Grove Drive Horsham, PA 19044 US
https://www.sciencedirect.com/science/article/pii/S0168365920301267
Furthermore, delivery of high-dose products such as monoclonal antibodies with increased viscosity can impact administration, syringeability, and device performance and may result in prolonged reconstitution times for lyophilized formulations.Author: David S. Collins, Manuel Sánchez-Félix, Advait V. Badkar, Randall Mrsny
https://biopharmadealmakers.nature.com/users/13785-portal-instruments/posts/17597-needle-free-solving-challenges-with-viscous-biologic-self-injections
Jun 06, 2017 · However, challenges exist with the delivery of biologics: to be effective, these biologics often need to be delivered at high doses, but regulatory bodies impose limits on the injectable volumes of drug formulations. The result is high-viscosity drug solutions.Author: Portal Instruments
https://www.mddionline.com/designing-drug-delivery-device-read-first
Jul 22, 2019 · Prefilled syringe or delivery device should be easy to use and injection should be less painful to the patient. Solution: While designing the drug delivery device, there are two sub-systems needs to be taken into consideration. One is the primary container system, which directly comes in contact with the drug formulation.
https://www.bioprocessingsummit.com/protein-formulations/15/
8:55 Viscosity in High-Concentration Protein Formulations. Thomas Palm, Ph.D., Senior Research Investigator II, Drug Product Science and Technology, Bristol-Myers Squibb Co. At high protein concentration, small changes in concentration or pH that are within the typical specification range can have a significant impact on product viscosity.
http://www.pharmtech.com/trends-biologics-drug-delivery
Sep 25, 2015 · Trends in Biologics Drug Delivery. ... “A wearable device allows drug delivery over a significantly longer period than the typical 10- to 20-second window associated with an autoinjector. Because of this feature, a wearable device can enable large-volume doses, or high-viscosity formulations, or even larger-volume payloads at high viscosity ...
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