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https://www.sciencedirect.com/science/article/pii/S0168365915302649
An overview of non-viral gene delivery tools for non-systemic administration. A) Nucleic acids (DNA, therapeutic oligonucleotides and gene editing) and bio- and nanotechnology tools, including ex vivo methods, used in non-viral gene therapy. B) Schematic diagram of the building blocks, delivery systems and non-invasive administration routes in ...Author: Marianna Foldvari, Ding Wen Chen, Nafiseh Nafissi, Daniella Calderon, Lokesh Narsineni, Amirreza Raf...
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
The successful delivery of therapeutic genes to the desired target cells and their availability at the intracellular site of action are crucial requirements for efficient gene therapy. The design of safe and efficient non-viral vectors depends mainly on our understanding of the mechanisms involved in the cellular uptake and intracellular ...Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · There are different viral and nonviral vectors for gene delivery, but all gene therapy applications depend on the fact that the genetic material needs to be delivered across the cell membrane and ultimately to the cell nucleus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782077/
Oct 16, 2009 · Gene therapy is becoming a promising therapeutic modality for the treatment of genetic and acquired disorders. Nonviral approaches as alternative gene transfer vehicles to the popular viral vectors have received significant attention because of their favorable properties, including lack of immunogenicity, low toxicity, and potential for tissue specificity.Author: Mohammed S. Al-Dosari, Xiang Gao
https://www.youtube.com/watch?v=B0zggFZvH9M
Dec 09, 2013 · This gene therapy video tutorial focuses on different non viral gene delivery system to deliver normal copy of gene inside host tissue to cure genetic diseases. For more information, log on to ...Author: Shomu's Biology
http://www.genetherapynet.com/non-viral-vectors.html
Non-viral methods present certain advantages over viral methods, with simple large scale production and low host immunogenicity being just two. Previously, low levels of transfection and expression of the gene held non-viral methods at a disadvantage; however, recent advances in vector technolog...
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