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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017392/
Apr 18, 2018 · Application of dendrimers as a drug delivery system started in late 1990s. Dendrimers for drug delivery are employed using two approaches: (i) formulation and (ii) nanoconstruct. In the formulation approach, drugs are physically entrapped in a dendrimer using non-covalent interactions, whereas drugs are covalently coupled on dendrimers in the nanoconstruct approach.Author: Abhay Singh Chauhan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097927/
Dendrimers for Gene Delivery Gene transfer is an invaluable experimental tool that involves the introduction of new genetic material to host for treatment of diseases. Various vectors and physical methods are reported for in vivo delivery of therapeutic nucleic acids.
https://www.sciencedirect.com/topics/chemistry/dendrimer
Dendrimers are attractive macromolecular systems for drug delivery because of their nanometer size range (5–20 nm), ease of preparation and functionalization, and their ability to display multiple copies of surface groups for biological recognition processes (Morgan and Cloninger, 2002). Dendrimer molecules are monodisperse symmetric macromolecules built around a small molecule or in a linear polymer …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074873/
May 21, 2014 · Dendrimers have found applications in transdermal drug delivery systems. Generally, in bioactive drugs having hydrophobic moieties in their structure and low water solubility, dendrimers are a good choice in the field of efficient delivery system [ 63 ].Author: Elham Abbasi, Sedigheh Fekri Aval, Abolfazl Akbarzadeh, Morteza Milani, Hamid Tayefi Nasrabadi, Sang...
https://www.worldofchemicals.com/19/chemistry-articles/dendrimers-for-drug-delivery.html
Dendrimers for drug delivery Abstract Dendrimers are novel and exciting class of highly branched three-dimensional polymer in which growth emanates from a central core molecule such as ammonia , ethylenediamine , and polydiamine or benzene tricarboxylic acid chloride .
https://www.sciencedirect.com/science/article/pii/S092849311733103X
Dendrimers, as a type of artificial polymers with unique structural features, have been extensively explored for their applications in biomedical fields, especially in drug delivery. However, one important concern about the most commonly used dendrimers exists - the nondegradability, which may cause side effects induced by the accumulation of synthetic polymers in cells or tissues.Author: Da Huang, Da Huang, Decheng Wu
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/dendrimers
Dendrimers that are used in drug delivery incorporate more than one polymers: polyamidoamine (PAMAM), polyethylenimine (PEI), chitin, melamine, poly(l-glutamic acid) (PG), poly(propyleneimine), and poly(ethylene glycol) (PEG) (Dykes, 2001).
https://www.sciencedirect.com/science/article/pii/S0079670013000853
Drug delivery scientists are especially enthusiastic about possible utility of dendrimers as drug delivery tool. Terminal functionalities provide a platform for conjugation of the drug and targeting moieties. In addition, these peripheral functional groups can be employed to tailor-make the properties of dendrimers, enhancing their versatility.Author: Prashant Kesharwani, Keerti Jain, Narendra Kumar Jain
https://www.sigmaaldrich.com/materials-science/material-science-products.html?TablePage=16375655
Dendrimers are highly branched, star-shaped macromolecules with nanometer-scale dimensions. Dendrimers are defined by three components: a central core, an interior dendritic structure (the branches), and an exterior surface with functional surface groups. They are synthesized by step-wise chemical methods to give distinct generations (G0, G1, G2, etc.) of molecules with narrow …
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