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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · The site of action of siRNA therapeutics is the cytosol. The barriers to siRNA delivery are multiple and depend on the targeted organs and the administration routes. In general, locoregional delivery of siRNA has fewer barriers compared to systemic delivery.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.sciencedirect.com/science/article/pii/S1818087614000646
If siRNA delivery provokes unacceptable toxicity on either a cellular or systemic level, even the most efficacious siRNA delivery system will be rendered useless. Viral vectors, which were among the first vehicles to be studied for siRNA delivery, can induce unacceptable levels of toxicity through the activation of immune responses .Author: Cong-fei Xu, Jun Wang
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · This Review provides an introduction to the biological challenges that siRNA delivery materials aim to overcome, as well as a discussion of the way that the …Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425738/
Apr 10, 2014 · Delivery of siRNA into keratinocytes using SPACE peptide. The ability of SPACE-peptide to facilitate internalization of GAPDH siRNA was verified (Fig. 7). GAPDH siRNA conjugated to SPACE peptide and co-incubated with 10 mg/mL free SPACE peptide …Author: Ming Chen, Michael Zakrewsky, Vivek Gupta, Aaron C. Anselmo, Deborah H. Slee, John A. Muraski, Samir...
https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · Delivery of therapeutic siRNA to specific tissues is a major challenge. Alvarez-Erviti et al. show that exosomes—small vesicles that are naturally secreted by many animal cells—can be ...Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://link.springer.com/protocol/10.1007%2F978-1-59745-191-8_6
The intranasal administration of siRNA has opened new vistas in drug delivery and respiratory therapy. In this strategy, synthetic siRNA with or without chemical modifications can be applied intranasally. Various delivery vehicles have been tested and optimized.Author: Vira Bitko, Sailen Barik
https://www.pnas.org/content/104/32/12982
Aug 07, 2007 · The ability of siRNA to silence specific genes has generated great interest in its use as a research tool and therapeutic agent for a wide spectrum of disorders that include cancer, infectious disease, and metabolic conditions (1–3).Effective in vivo delivery of siRNA to the appropriate target cell is an essential component of these siRNA-based applications.Author: David B. Rozema, David L. Lewis, Darren H. Wakefield, So C. Wong, Jason J. Klein, Paula L. Roesch, S...
https://www.sciencedirect.com/science/article/pii/S0168365918302190
Additionally, there were significant difference in the plaques burden between CT/siRNA and C/siRNA group, which might result from the effective delivery of siRNA into the brain neuron cells in the CT/siRNA group with specific inhibition of the production of toxic isoform Aβ42 (Fig. S9).Author: Pengzhen Wang, Xiaoyao Zheng, Qian Guo, Peng Yang, Xiaoying Pang, Kang Qian, Wei Lu, Qizhi Zhang, Xi...
http://altogenlabs.com/rna-interference-rnai-services/in-vivo-sirna-delivery-and-tissue-targeting/
In Vivo siRNA Delivery and Tissue Targeting (In Vivo RNAi) In Vivo siRNA Delivery and Tissue Targeting. RNAi-induced gene silencing is used to study gene function in cultured cells (in vitro).Most often, these effects are induced by the introduction of small-interfering RNA (siRNA) or microRNA (miRNA).
https://www.sigmaaldrich.com/technical-documents/articles/biology/sirna-difficult-cells.html
The siRNA is a 19- to 25-bp dsRNA that can activate the RISC enzyme. The crucial factor in using siRNA is the successful delivery of the siRNA oligonucleotides to cultured cells. The siRNAs are often delivered into cells using transfection reagents; however, efficient siRNA delivery is difficult in some cell lines.
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