Delivery And Sirna

We have collected information about Delivery And Sirna for you. Follow the links to find out details on Delivery And Sirna.


Delivery of siRNA Therapeutics: Barriers and Carriers

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
    Jun 11, 2010 · The site of action of siRNA therapeutics is the cytosol. The barriers to siRNA delivery are multiple and depend on the targeted organs and the administration routes. In general, locoregional delivery of siRNA has fewer barriers compared to systemic delivery.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au

Delivery systems for siRNA drug development in cancer therapy

    https://www.sciencedirect.com/science/article/pii/S1818087614000646
    If siRNA delivery provokes unacceptable toxicity on either a cellular or systemic level, even the most efficacious siRNA delivery system will be rendered useless. Viral vectors, which were among the first vehicles to be studied for siRNA delivery, can induce unacceptable levels of toxicity through the activation of immune responses .Author: Cong-fei Xu, Jun Wang

Delivery materials for siRNA therapeutics Nature Materials

    https://www.nature.com/articles/nmat3765
    Oct 23, 2013 · This Review provides an introduction to the biological challenges that siRNA delivery materials aim to overcome, as well as a discussion of the way that the …Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson

Topical Delivery of siRNA into Skin using SPACE-peptide ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425738/
    Apr 10, 2014 · Delivery of siRNA into keratinocytes using SPACE peptide. The ability of SPACE-peptide to facilitate internalization of GAPDH siRNA was verified (Fig. 7). GAPDH siRNA conjugated to SPACE peptide and co-incubated with 10 mg/mL free SPACE peptide …Author: Ming Chen, Michael Zakrewsky, Vivek Gupta, Aaron C. Anselmo, Deborah H. Slee, John A. Muraski, Samir...

Delivery of siRNA to the mouse brain by systemic injection ...

    https://www.nature.com/articles/nbt.1807
    Mar 20, 2011 · Delivery of therapeutic siRNA to specific tissues is a major challenge. Alvarez-Erviti et al. show that exosomes—small vesicles that are naturally secreted by many animal cells—can be ...Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood

Nasal Delivery of siRNA SpringerLink

    https://link.springer.com/protocol/10.1007%2F978-1-59745-191-8_6
    The intranasal administration of siRNA has opened new vistas in drug delivery and respiratory therapy. In this strategy, synthetic siRNA with or without chemical modifications can be applied intranasally. Various delivery vehicles have been tested and optimized.Author: Vira Bitko, Sailen Barik

Dynamic PolyConjugates for targeted in vivo delivery of ...

    https://www.pnas.org/content/104/32/12982
    Aug 07, 2007 · The ability of siRNA to silence specific genes has generated great interest in its use as a research tool and therapeutic agent for a wide spectrum of disorders that include cancer, infectious disease, and metabolic conditions (1–3).Effective in vivo delivery of siRNA to the appropriate target cell is an essential component of these siRNA-based applications.Author: David B. Rozema, David L. Lewis, Darren H. Wakefield, So C. Wong, Jason J. Klein, Paula L. Roesch, S...

Systemic delivery of BACE1 siRNA through neuron-targeted ...

    https://www.sciencedirect.com/science/article/pii/S0168365918302190
    Additionally, there were significant difference in the plaques burden between CT/siRNA and C/siRNA group, which might result from the effective delivery of siRNA into the brain neuron cells in the CT/siRNA group with specific inhibition of the production of toxic isoform Aβ42 (Fig. S9).Author: Pengzhen Wang, Xiaoyao Zheng, Qian Guo, Peng Yang, Xiaoying Pang, Kang Qian, Wei Lu, Qizhi Zhang, Xi...

In Vivo siRNA Delivery and Tissue Targeting (In Vivo RNAi ...

    http://altogenlabs.com/rna-interference-rnai-services/in-vivo-sirna-delivery-and-tissue-targeting/
    In Vivo siRNA Delivery and Tissue Targeting (In Vivo RNAi) In Vivo siRNA Delivery and Tissue Targeting. RNAi-induced gene silencing is used to study gene function in cultured cells (in vitro).Most often, these effects are induced by the introduction of small-interfering RNA (siRNA) or microRNA (miRNA).

siRNA Delivery in Mammalian Cell Lines Sigma-Aldrich

    https://www.sigmaaldrich.com/technical-documents/articles/biology/sirna-difficult-cells.html
    The siRNA is a 19- to 25-bp dsRNA that can activate the RISC enzyme. The crucial factor in using siRNA is the successful delivery of the siRNA oligonucleotides to cultured cells. The siRNAs are often delivered into cells using transfection reagents; however, efficient siRNA delivery is difficult in some cell lines.

Searching for Delivery And Sirna?

You can just click the links above. The data is collected for you.

Related Delivery Info